Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.38 |
| ▸ | AKT1 | P31749 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 2/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7682463 | 0.86 | HRH3 (0.36) | CYP1A2CYP2C9PIK3CAPIK3CDPIK3CG | |
| SCHEMBL7675337 | 0.80 | PIK3R1 (0.40) | CYP1A2CYP2C9PIK3CAPIK3CDPIK3CG | |
| SCHEMBL7672759 | 0.76 | KDM4E (0.43) | CYP1A2CYP2C9PIK3CAPIK3CDKDM4E | |
| SCHEMBL7673338 | 0.75 | HRH3 (0.40) | CYP1A2CYP2C9PIK3CAPIK3CDPIK3CG | |
| SCHEMBL7675925 | 0.68 | CYP2D6 (0.45) | KDM4E | |
| SCHEMBL7679170 | 0.68 | CYP2C19 (0.53) | KDM4EGAA | |
| SCHEMBL27501203 | 0.67 | CHIA (0.35) | HRH4PIK3CAKDM4EGAAHRH3 | |
| SCHEMBL1599910 | 0.66 | KDM4E (0.45) | CYP1A2CYP2C9PIK3CAKDM4EGAA | |
| SCHEMBL1602160 | 0.66 | KDM4E (0.45) | CYP1A2CYP2C9PIK3CAKDM4EGAA | |
| SCHEMBL7679097 | 0.66 | CYP2C19 (0.48) | PIK3CAGAAHRH3MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1146542-C | Benzamide derivatives and their use as cytokine inhibitors | — | 2004-04-21 | — | — | CN | disclosed |
| US-6455520-B1 | TUMOR NECROSIS FACTOR AND INTERLEUKIN INHIBITORS; ANTIINFLAMMATORY AGENTS, ANTIALLERGENS; BONE DISORDERS | ASTRA ZENECA AB (SE) | 2002-09-24 | — | — | US | disclosed |
| CN-1319092-A | Benzamide derivatives and their use as cytokine inhibitors | ASTRAZENECA AB (SE) | 2001-10-24 | — | — | CN | disclosed |