Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7673338 | 0.81 | HRH3 (0.40) | PIK3CAPIK3CDLRRK2CYP1A2CYP2C9 | |
| SCHEMBL7682463 | 0.78 | HRH3 (0.36) | PIK3CAPIK3CDLRRK2CYP1A2CYP2C9 | |
| SCHEMBL7675337 | 0.77 | PIK3R1 (0.40) | KDM4EPIK3CAHSD17B10LMNAPIK3CD | |
| SCHEMBL7674582 | 0.76 | HRH4 (0.38) | KDM4EPIK3CAPIK3CDLRRK2CYP1A2 | |
| SCHEMBL7675925 | 0.75 | CYP2D6 (0.45) | KDM4EALDH1A1TSHRCYP2C19SMN1; SMN2 | |
| SCHEMBL7679170 | 0.74 | CYP2C19 (0.53) | KDM4EALDH1A1LMNAKMT2APOLB | |
| SCHEMBL7678922 | 0.74 | HRH3 (0.39) | KDM4EALDH1A1TSHRLMNATLR7 | |
| SCHEMBL7679625 | 0.74 | HRH3 (0.39) | KDM4EALDH1A1TSHRLMNATLR7 | |
| SCHEMBL7679097 | 0.72 | CYP2C19 (0.48) | ALDH1A1PIK3CAKMT2APOLBTLR7 | |
| SCHEMBL7680859 | 0.72 | HTR2C (0.38) | TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6455520-B1 | TUMOR NECROSIS FACTOR AND INTERLEUKIN INHIBITORS; ANTIINFLAMMATORY AGENTS, ANTIALLERGENS; BONE DISORDERS | ASTRA ZENECA AB (SE) | 2002-09-24 | — | — | US | disclosed |