Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R1 | P27986 | 15/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 15/20 | 0.40 |
| ▸ | MTOR | P42345 | 10/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7674582 | 0.80 | HRH4 (0.38) | PIK3CAMTORGAAPIK3CDPIK3CB | |
| SCHEMBL7682463 | 0.80 | HRH3 (0.36) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL7673338 | 0.78 | HRH3 (0.40) | PIK3R1PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL7672759 | 0.77 | KDM4E (0.43) | PIK3CALMNAPIK3CDCYP1A2CYP2C9 | |
| SCHEMBL7675387 | 0.69 | PIK3CA (0.44) | PIK3R1PIK3CALMNAGAAPIK3CD | |
| SCHEMBL7675925 | 0.69 | CYP2D6 (0.45) | KDM4E | |
| SCHEMBL7679170 | 0.68 | CYP2C19 (0.53) | LMNAGAAKDM4E | |
| SCHEMBL7678922 | 0.68 | HRH3 (0.39) | LMNAGAACYP1A2CYP2C9KDM4E | |
| SCHEMBL1599910 | 0.67 | KDM4E (0.45) | PIK3CALMNAGAAMAPK1CYP1A2 | |
| SCHEMBL1602160 | 0.67 | KDM4E (0.45) | PIK3CALMNAGAAMAPK1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6455520-B1 | TUMOR NECROSIS FACTOR AND INTERLEUKIN INHIBITORS; ANTIINFLAMMATORY AGENTS, ANTIALLERGENS; BONE DISORDERS | ASTRA ZENECA AB (SE) | 2002-09-24 | — | — | US | disclosed |