Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 4/20 | 0.48 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | KLK7 | P49862 | 2/20 | 0.37 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.34 |
| ▸ | CDC25B | P30305 | 4/20 | 0.34 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.34 |
| ▸ | CDC25A | P30304 | 2/20 | 0.34 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | REN | P00797 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | TLR2 | O60603 | 1/20 | 0.32 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7972109 | 0.88 | GHSR (0.60) | GHSR | |
| SCHEMBL7610297 | 0.85 | CCKBR (0.43) | CTSSKLK7CTSLCCKARCCKBR | |
| SCHEMBL5248481 | 0.78 | GHSR (0.79) | GHSRPPARACTSSKLK7KLK5 | |
| SCHEMBL5248471 | 0.78 | GHSR (0.79) | GHSRPPARACTSSKLK7KLK5 | |
| SCHEMBL5253549 | 0.78 | GHSR (0.79) | GHSRPPARACTSSKLK7KLK5 | |
| Hydrochloric Acid SCHEMBL7958646 | 0.77 | GHSR (0.48) | GHSR | |
| SCHEMBL5299121 | 0.76 | GHSR (0.63) | GHSRPPARACTSSKLK7KLK5 | |
| SCHEMBL5299114 | 0.76 | GHSR (0.63) | GHSRPPARACTSSKLK7KLK5 | |
| SCHEMBL5254132 | 0.74 | GHSR (0.73) | GHSRPPARACTSSPPARGCCKBR | |
| SCHEMBL5254137 | 0.74 | GHSR (0.73) | GHSRPPARACTSSPPARGCCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6482825-B2 | HEXAHYDRO-PYRAZOLO-(4,3-C)PYRIDINE DERIVATIVES USEFUL FOR INCREASING THE ENDOGENOUS PRODUCTION OR RELEASE OF GROWTH HORMONE IN A HUMAN OR OTHER ANIMAL, THUS TREAT OR PREVENT OSTEOPOROSIS | PFIZER INC. | 2002-11-19 | — | — | US | disclosed |