Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | PDE4A | P27815 | 1/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2779361 | 0.86 | KMT2A (0.65) | KMT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL13692388 | 0.86 | TDP1 (0.72) | KMT2ATDP1RAB9AALDH1A1GAA | |
| SCHEMBL7373227 | 0.85 | TDP1 (0.76) | KMT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4165132 | 0.85 | RAB9A (0.74) | KMT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29125555 | 0.85 | KMT2A (0.60) | KMT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29719568 | 0.85 | KMT2A (0.60) | KMT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27512619 | 0.84 | KMT2A (0.56) | KMT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3454518 | 0.82 | POLB (0.61) | KMT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7911632 | 0.81 | ALDH1A1 (0.77) | KMT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7001893 | 0.81 | KMT2A (0.49) | KMT2APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |