Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4A | P47712 | 3/20 | 0.56 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.56 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7679479 | 0.89 | PLA2G4A (0.72) | PLA2G4ALTB4R | |
| SCHEMBL7676318 | 0.87 | PLA2G4A (0.55) | PLA2G4ALTB4R | |
| SCHEMBL7674800 | 0.85 | PLA2G4A (0.55) | PLA2G4ALTB4R | |
| SCHEMBL7676175 | 0.82 | PLA2G4A (0.72) | PLA2G4ALTB4R | |
| SCHEMBL8119691 | 0.78 | PLA2G4A (0.83) | PLA2G4A | |
| SCHEMBL8422991 | 0.77 | HDAC1 (0.46) | PLA2G4A | |
| SCHEMBL22769033 | 0.76 | EPHX2 (0.50) | — | |
| SCHEMBL7679762 | 0.76 | PLA2G4A (0.71) | PLA2G4ALTB4R | |
| SCHEMBL7682643 | 0.74 | PLA2G4A (0.74) | PLA2G4ALTB4R | |
| SCHEMBL7682333 | 0.72 | PLA2G4A (1.00) | PLA2G4ALTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1062205-A2 | INHIBITORS OF PHOSPHOLIPASE ENZYMES | GENETICS INSTITUTE, INC. (US) | 2000-12-27 | — | — | EP | claimed |
| WO-1999043654-A2 | INHIBITORS OF PHOSPHOLIPASE ENZYMES | GENETICS INSTITUTE, INC. (US) | 1999-09-02 | — | — | WO | claimed |
| US-6500853-B1 | ENZYME INHIBITORS SUCH AS 4-((1-BENZHYDRYL-5-(((BUTYLAMINO)-CARBONYL)AMINO)-1H-INDOL-3-YL)METHYL)-3 -METHOXYBENZOIC ACID USED AS ANTIINFLAMMATORY AGENTS FOR PROPHYLAXIS OF ARTHRITIS, INFLAMMATORY BOWEL DISEASE OR ASTHMA | GENETICS INSTITUTE, LLC | 2002-12-31 | — | — | US | disclosed |