Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.36 |
| ▸ | BAD | Q92934 | 1/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.36 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KCNA3 | P22001 | 4/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | BRS3 | P32247 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7674887 | 1.00 | NAMPT (0.39) | NAMPTBCL2L1BADAGTR1AGTR2 | |
| SCHEMBL7668232 | 0.89 | SLC6A4 (0.42) | NAMPTMEN1KMT2AKCNA3GRM2 | |
| SCHEMBL7668237 | 0.89 | SLC6A4 (0.42) | NAMPTMEN1KMT2AKCNA3GRM2 | |
| SCHEMBL7671975 | 0.84 | AGTR1 (0.49) | BCL2L1BADAGTR1AGTR2KCNA3 | |
| SCHEMBL7671974 | 0.84 | AGTR1 (0.49) | BCL2L1BADAGTR1AGTR2KCNA3 | |
| SCHEMBL7670346 | 0.81 | FNTA (0.49) | — | |
| SCHEMBL7670339 | 0.81 | FNTA (0.49) | — | |
| SCHEMBL7667006 | 0.80 | NAMPT (0.39) | NAMPTBCL2L1BADKCNA3KDM4A | |
| SCHEMBL7667000 | 0.80 | NAMPT (0.39) | NAMPTBCL2L1BADKCNA3KDM4A | |
| SCHEMBL7668332 | 0.77 | BCL2L1 (0.38) | NAMPTBCL2L1BADKCNA3BRS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6486156-B1 | Chemical compounds | ASTRAZENECA AB (SE) | 2002-11-26 | — | — | US | disclosed |
| EP-1140858-A2 | ARYLPROPENYLIMIDAZOLES AS FARNESYL-PROTEIN TRANSFERASE INHIBITORS | AstraZeneca AB (SE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039716-A2 | ARYLPROPENYLIMIDAZOLES AS FARNESYL-PROTEIN TRANSFERASE INHIBITORS | ASTRAZENECA AB (SE) | 2000-07-06 | — | — | WO | disclosed |