Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.33 |
| ▸ | CENPE | Q02224 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6858279 | 0.92 | PDE5A (0.42) | PDE5A | |
| SCHEMBL6764887 | 0.91 | MEN1 (0.40) | MEN1KMT2AS1PR1PDE10ATP53 | |
| SCHEMBL7680595 | 0.91 | PDE5A (0.36) | KMT2APDE10APDE5AALDH1A1DGAT1 | |
| Bicarbonate SCHEMBL6214376 | 0.90 | PDE5A (0.41) | MEN1KMT2AS1PR1PDE10ATP53 | |
| SCHEMBL7674199 | 0.89 | PDE10A (0.39) | PDE10APDE5AALDH1A1GAADGAT1 | |
| SCHEMBL6767775 | 0.87 | MEN1 (0.38) | MEN1KMT2AS1PR1PDE10ATP53 | |
| SCHEMBL6852827 | 0.87 | HSD17B10 (0.39) | PDE10APDE5AALDH1A1GAADGAT1 | |
| SCHEMBL6858363 | 0.86 | PDE5A (0.41) | PDE5A | |
| SCHEMBL6861041 | 0.84 | TRPV1 (0.40) | MEN1KMT2A | |
| Beminafil SCHEMBL2421274 | 0.83 | PDE5A (0.47) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6495557-B1 | SUCH AS 3-(4-(3-CHLORO-4-METHOXYBENZYLAMINO)BENZO-(4,5)-THIENO (2,3-D)PYRIMIDIN-2-YL)PROPIONIC ACID; CARDIOVASCULAR DISORDERS AND/OR IMPAIRED POTENCY | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2002-12-17 | — | — | US | disclosed |