Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 6/20 | 0.40 |
| ▸ | NPY1R | P25929 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | RAB9A | P51151 | 4/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7674366 | 1.00 | CRHR1 (0.40) | CRHR1NPY1RCHRM2ALDH1A1MAPT | |
| SCHEMBL7677576 | 0.86 | CRHR1 (0.39) | CRHR1NPY1RALDH1A1KDM4EGAA | |
| SCHEMBL7674360 | 0.78 | CRHR1 (0.39) | CRHR1NPY1RALDH1A1MAPTKDM4E | |
| SCHEMBL7675191 | 0.78 | CRHR1 (0.39) | CRHR1NPY1RALDH1A1MAPTKDM4E | |
| SCHEMBL7677573 | 0.75 | CRHR1 (0.39) | CRHR1 | |
| SCHEMBL7788898 | 0.75 | CRHR1 (0.48) | CRHR1NPY1RALDH1A1MAPTKDM4E | |
| SCHEMBL7788907 | 0.73 | CRHR1 (0.42) | CRHR1NPY1RALDH1A1MAPTKDM4E | |
| SCHEMBL7677887 | 0.73 | CRHR1 (0.45) | CRHR1ALDH1A1MAPTKDM4EGAA | |
| SCHEMBL7679938 | 0.72 | CRHR1 (0.47) | CRHR1 | |
| SCHEMBL7677542 | 0.72 | CRHR1 (0.39) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6147085-A | Aminoalkyl substituted 9H-pyridino[2,3-b] indole and 9H-pyrimidino[4,5-b] indole derivatives | NEUROGEN CORPORATION (US) | 2000-11-14 | — | — | US | claimed |
| US-6362186-B1 | PSYCHOLOGICAL DISORDERS | NEUROGEN CORPORATION | 2002-03-26 | — | — | US | disclosed |
| US-6147085-A | Aminoalkyl substituted 9H-pyridino[2,3-b] indole and 9H-pyrimidino[4,5-b] indole derivatives | NEUROGEN CORPORATION (US) | 2000-11-14 | — | — | US | disclosed |