Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.48 |
| ▸ | CCR1 | P32246 | 4/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.39 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.39 |
| ▸ | DRD1 | P21728 | 3/20 | 0.39 |
| ▸ | HRH2 | P25021 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11274934 | 0.83 | CCR1 (0.48) | LMNACYP2D6CCR1SLC6A4SLC6A2 | |
| SCHEMBL13867524 | 0.82 | LMNA (0.52) | LMNACYP2D6CCR1SLC6A4MAPT | |
| SCHEMBL9469648 | 0.79 | SLC6A4 (0.43) | LMNACYP2D6CCR1SLC6A4SLC6A2 | |
| SCHEMBL9426817 | 0.79 | CCR1 (0.45) | LMNACCR1ALDH1A1CHRM2HTR2A | |
| SCHEMBL8255534 | 0.79 | CCR1 (0.45) | LMNACYP2D6CCR1ALDH1A1CHRM2 | |
| SCHEMBL8251316 | 0.79 | CCR1 (0.45) | LMNACCR1ALDH1A1HTR2ARET | |
| SCHEMBL13548795 | 0.78 | CCR1 (0.44) | LMNACYP2D6CCR1MAPTALDH1A1 | |
| SCHEMBL9845104 | 0.76 | CCR1 (0.52) | LMNACYP2D6CCR1ALDH1A1HTR2A | |
| SCHEMBL13552352 | 0.76 | CCR1 (0.44) | LMNACCR1ALDH1A1CHRM2HTR2A | |
| SCHEMBL11271288 | 0.76 | CCR1 (0.52) | LMNACYP2D6CCR1SLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6387893-B1 | ADRENERGIC BLOCKING AGENT; BENIGN PROSATATIC HYPERPLASIA | MERCK & CO., INC. | 2002-05-14 | — | — | US | disclosed |