Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTRC | Q99895 | 4/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | LDHA | P00338 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.45 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4259978 | 0.87 | CTRC (0.77) | CTRCKDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL10917470 | 0.83 | CTRC (1.00) | CTRCKDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL732748 | 0.82 | KDM4E (0.51) | CTRCKDM4EHSP90AA1HSP90AB1SMN1; SMN2 | |
| SCHEMBL28187952 | 0.81 | CTRC (0.53) | CTRCKDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL4490449 | 0.81 | CHEK1 (0.57) | CTRCKDM4ESMN1; SMN2ALDH1A1MCL1 | |
| SCHEMBL27738184 | 0.81 | ADORA3 (0.53) | CTRCSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL7675313 | 0.80 | CTRC (0.63) | CTRCKDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL4496585 | 0.79 | CTRC (0.47) | CTRCSMN1; SMN2MEN1KMT2AHPGD | |
| SCHEMBL20346112 | 0.79 | CTRC (0.61) | CTRCKDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL18363001 | 0.79 | CTRC (0.61) | CTRCKDM4ESMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1146542-C | Benzamide derivatives and their use as cytokine inhibitors | — | 2004-04-21 | — | — | CN | disclosed |
| US-6455520-B1 | TUMOR NECROSIS FACTOR AND INTERLEUKIN INHIBITORS; ANTIINFLAMMATORY AGENTS, ANTIALLERGENS; BONE DISORDERS | ASTRA ZENECA AB (SE) | 2002-09-24 | — | — | US | disclosed |
| CN-1319092-A | Benzamide derivatives and their use as cytokine inhibitors | ASTRAZENECA AB (SE) | 2001-10-24 | — | — | CN | disclosed |
| EP-1115707-A1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | AstraZeneca AB (SE) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018738-A1 | BENZAMIDE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2000-04-06 | — | — | WO | disclosed |