Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | PTGES | O14684 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.51 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.51 |
| ▸ | PPARG | P37231 | 6/20 | 0.50 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | TNF | P01375 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.47 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7676720 | 0.94 | TDP1 (0.55) | TDP1PTGESTP53ALDH1A1HPGD | |
| SCHEMBL7673926 | 0.92 | TDP1 (0.62) | TDP1PTGESTP53ALDH1A1MAPT | |
| SCHEMBL7674883 | 0.89 | TDP1 (0.54) | TDP1PTGESTP53ALDH1A1MAPT | |
| SCHEMBL6170472 | 0.89 | PTGES (0.62) | TDP1PTGESTP53ALDH1A1MAPT | |
| SCHEMBL6170375 | 0.89 | AGTR1 (0.62) | TDP1PTGESTP53AGTR1AGTR2 | |
| SCHEMBL7671121 | 0.89 | AGTR1 (0.54) | TDP1PTGESTP53ALDH1A1MAPT | |
| SCHEMBL6170532 | 0.88 | AGTR1 (0.55) | TDP1PTGESTP53ALDH1A1MAPT | |
| SCHEMBL6170528 | 0.85 | TP53 (0.55) | TDP1PTGESTP53ALDH1A1MAPT | |
| SCHEMBL7668569 | 0.85 | TDP1 (0.52) | TDP1PTGESTP53ALDH1A1MAPT | |
| SCHEMBL7674177 | 0.84 | PDE2A (0.55) | TDP1PTGESTP53ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6352985-B1 | CARDIOVASCULAR DISORDERS OR GASTROINTESTINAL DISORDERS, DIABETES (TYPE II DIABETES), DIABETIC COMPLICATIONS METHOD FOR LOWERING THE BLOOD SUGAR LEVEL OF A PATIENT, | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-03-05 | — | — | US | disclosed |
| EP-1132087-A1 | REMEDIES FOR POLYCYSTIC OVARY SYNDROME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-09-12 | — | — | EP | disclosed |
| US-6166219-A | Benzimidazole derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-12-26 | — | — | US | disclosed |
| EP-0882718-A1 | BENZIMIDAZOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-12-09 | — | — | EP | disclosed |