Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KMO | O15229 | 1/20 | 0.46 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11467792 | 0.88 | LMNA (0.58) | MAPK14LMNAKMOALDH1A1GAA | |
| SCHEMBL5813593 | 0.82 | MAPK14 (0.46) | MAPK14LMNAKMOTDO2CSNK1A1 | |
| SCHEMBL7222330 | 0.82 | MAPK14 (0.52) | MAPK14LMNAKMOADORA2AADORA1 | |
| SCHEMBL5812149 | 0.81 | MAPK14 (0.44) | MAPK14LMNAKMOTDO2DYRK3 | |
| SCHEMBL5817815 | 0.81 | MAPK14 (0.44) | MAPK14LMNAKMOADORA2AADORA1 | |
| SCHEMBL6999911 | 0.81 | MAPK14 (0.47) | MAPK14LMNAKMOADORA2AADORA1 | |
| SCHEMBL7215845 | 0.79 | MAPK14 (0.63) | MAPK14LMNAKMOCSNK1DADORA2A | |
| SCHEMBL14561099 | 0.78 | MAPK14 (0.49) | MAPK14LMNAALDH1A1CCNA2CDK2 | |
| SCHEMBL14561096 | 0.78 | MAPK14 (0.47) | MAPK14LMNAKMOALDH1A1GAA | |
| SCHEMBL5410735 | 0.78 | MAPK14 (0.54) | MAPK14LMNAKMOALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350744-B1 | PYRMIDINE OR PYRIDINE DERIVATIVES; ANTIARTHRITIC AND ANTIINFLAMMATORY AGENTS; CACHEXIA TREATMENT; INTERLEUKIN AND TUMOR NECROSIS FACTOR INHIBITORS | MERCK & CO., INC. | 2002-02-26 | — | — | US | disclosed |