Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.63 |
| ▸ | MAPK11 | Q15759 | 11/20 | 0.63 |
| ▸ | MAPK13 | O15264 | 9/20 | 0.63 |
| ▸ | MAPK12 | P53778 | 9/20 | 0.63 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7222330 | 0.86 | MAPK14 (0.52) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL6999911 | 0.85 | MAPK14 (0.47) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL7215386 | 0.82 | MAPK11 (0.61) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL11467792 | 0.80 | LMNA (0.58) | MAPK14LMNAKMO | |
| SCHEMBL7676136 | 0.79 | MAPK14 (0.50) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL7216283 | 0.79 | MAPK14 (0.44) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL7215859 | 0.78 | MAPK13 (0.67) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL7215839 | 0.77 | MAPK14 (0.69) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL1384875 | 0.77 | MAPK14 (0.45) | MAPK14MAPK11MAPK13MAPK12LMNA | |
| SCHEMBL2929605 | 0.75 | MAPK14 (0.41) | MAPK14MAPK11MAPK13MAPK12MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602872-B1 | Substituted pyridazines having cytokine inhibitory activity | MERCK & CO., INC. | 2003-08-05 | — | — | US | disclosed |