Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CCR2 | P41597 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7508693 | 0.85 | MAPT (0.60) | MAPTLMNAABCB11TP53CCR2 | |
| SCHEMBL7679550 | 0.83 | MAPT (0.62) | MAPTLMNAABCB11TP53CCR2 | |
| SCHEMBL7680923 | 0.83 | ABCB11 (0.65) | MAPTLMNAABCB11TP53CCR2 | |
| SCHEMBL7511032 | 0.82 | MAPT (0.59) | MAPTLMNAABCB11TP53CCR2 | |
| SCHEMBL7681355 | 0.82 | MAPT (0.61) | MAPTLMNAABCB11TP53CCR2 | |
| SCHEMBL7683084 | 0.80 | MAPT (0.61) | MAPTLMNAABCB11TP53CCR2 | |
| SCHEMBL7517302 | 0.78 | MAPT (0.80) | MAPTLMNAABCB11TP53SMN1; SMN2 | |
| SCHEMBL7679796 | 0.75 | MAPT (0.80) | MAPTLMNAABCB11TP53SMN1; SMN2 | |
| SCHEMBL7701288 | 0.75 | MAPT (0.76) | MAPTLMNAABCB11TP53SMN1; SMN2 | |
| SCHEMBL7682546 | 0.74 | ABCB11 (0.76) | MAPTLMNAABCB11TP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6479527-B1 | Bicyclic pyrrole derivatives as MCP-1 inhibitors | ASTRAZENECA UK LIMITED (GB) | 2002-11-12 | — | — | US | disclosed |