Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.76 |
| ▸ | LMNA | P02545 | 1/20 | 0.74 |
| ▸ | TP53 | P04637 | 3/20 | 0.66 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | THRB | P10828 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7679796 | 0.92 | MAPT (0.80) | MAPTLMNATP53ABCB11SMN1; SMN2 | |
| SCHEMBL7680884 | 0.88 | ABCB11 (0.81) | MAPTLMNATP53ABCB11ALDH1A1 | |
| SCHEMBL7682546 | 0.81 | ABCB11 (0.76) | MAPTLMNATP53ABCB11SMN1; SMN2 | |
| SCHEMBL7680461 | 0.79 | ABCB11 (0.81) | MAPTLMNATP53ABCB11ALDH1A1 | |
| SCHEMBL7680923 | 0.78 | ABCB11 (0.65) | MAPTLMNATP53ABCB11SMN1; SMN2 | |
| SCHEMBL7679550 | 0.78 | MAPT (0.62) | MAPTLMNATP53ABCB11SMN1; SMN2 | |
| SCHEMBL7691746 | 0.78 | ABCB11 (1.00) | MAPTLMNAABCB11 | |
| SCHEMBL7681355 | 0.77 | MAPT (0.61) | MAPTLMNATP53ABCB11SMN1; SMN2 | |
| SCHEMBL7508693 | 0.77 | MAPT (0.60) | MAPTLMNATP53ABCB11SMN1; SMN2 | |
| SCHEMBL7511032 | 0.76 | MAPT (0.59) | MAPTLMNATP53ABCB11SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6479527-B1 | Bicyclic pyrrole derivatives as MCP-1 inhibitors | ASTRAZENECA UK LIMITED (GB) | 2002-11-12 | — | — | US | disclosed |