Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 6/20 | 0.54 |
| ▸ | SIRT1 | Q96EB6 | 9/20 | 0.51 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.47 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7852925 | 0.99 | KIF11 (0.53) | KIF11SIRT1MAPKAPK2SIRT2SIRT3 | |
| SCHEMBL7680175 | 0.98 | KIF11 (0.54) | KIF11SIRT1MAPKAPK2SIRT2SIRT3 | |
| SCHEMBL7851681 | 0.90 | SIRT1 (0.54) | KIF11SIRT1SIRT2SIRT3LMNA | |
| Hydrochloric Acid SCHEMBL7683415 | 0.89 | SIRT1 (0.53) | KIF11SIRT1SIRT2SIRT3LMNA | |
| SCHEMBL7677808 | 0.89 | SIRT1 (0.55) | KIF11SIRT1SIRT2SIRT3LMNA | |
| SCHEMBL7677047 | 0.86 | MEN1 (0.55) | KIF11SIRT1MAPKAPK2SIRT2SIRT3 | |
| SCHEMBL7855814 | 0.86 | MAPKAPK2 (0.66) | SIRT1MAPKAPK2SMN1; SMN2TP53MAPT | |
| SCHEMBL7680030 | 0.86 | SIRT1 (0.62) | KIF11SIRT1MAPKAPK2SIRT2SIRT3 | |
| Hydrochloric Acid SCHEMBL7674550 | 0.85 | MEN1 (0.53) | KIF11SIRT1MAPKAPK2SIRT2SIRT3 | |
| SCHEMBL7854483 | 0.84 | MAPKAPK2 (0.66) | SIRT1MAPKAPK2SMN1; SMN2TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350757-B1 | Beta-carboline compounds | LES LABORATOIRES SERVIER (FR) | 2002-02-26 | — | — | US | disclosed |
| EP-1070716-A1 | Beta-carboline derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2001-01-24 | — | — | EP | disclosed |