Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.30 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2112008 | 0.76 | PDGFRB (0.42) | KMT2A | |
| SCHEMBL2115933 | 0.75 | KDR (0.44) | — | |
| SCHEMBL28165269 | 0.65 | KDM4E (0.55) | KDM4EKMT2AALDH1A1MAPTPKM | |
| SCHEMBL2400948 | 0.64 | KDM4E (0.40) | KDM4EKMT2AALDH1A1MAPTPKM | |
| SCHEMBL15190326 | 0.63 | KDM4E (0.40) | KDM4EKMT2AALDH1A1MAPTPKM | |
| SCHEMBL27620206 | 0.60 | KDM4E (0.37) | KDM4EKMT2AALDH1A1MAPTPKM | |
| SCHEMBL15190313 | 0.60 | CYP19A1 (0.62) | KDM4ECYP24A1TBXA2R | |
| SCHEMBL28752330 | 0.60 | POLB (0.36) | KDM4EMAPTALOX12HTT | |
| SCHEMBL16150962 | 0.57 | ALDH1A1 (0.44) | KDM4EKMT2AALDH1A1MAPTPKM | |
| SCHEMBL4763771 | 0.57 | CYP17A1 (0.41) | KDM4EALDH1A1CYP24A1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255752-A2 | PYRROLE SUBSTITUTED 2-INDOLINONE PROTEIN KINASE INHIBITORS | Sugen, Inc. (US) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001060814-A2 | PYRROLE SUBSTITUTED 2-INDOLINONE PROTEIN KINASE INHIBITORS | SUGEN, INC. (US) | 2001-08-23 | — | — | WO | disclosed |