Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | RECQL | P46063 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7563359 | 0.87 | MAPT (0.70) | MAPTALDH1A1KDM4EL3MBTL1GAA | |
| SCHEMBL7848449 | 0.84 | MAPT (0.65) | MAPTALDH1A1KDM4EL3MBTL1GAA | |
| SCHEMBL7669468 | 0.83 | MMP9 (0.58) | MAPTALDH1A1KDM4EL3MBTL1MEN1 | |
| SCHEMBL7851242 | 0.83 | MAPT (0.64) | MAPTALDH1A1KDM4EL3MBTL1GAA | |
| SCHEMBL7855516 | 0.83 | MAPT (0.64) | MAPTALDH1A1KDM4EL3MBTL1GAA | |
| SCHEMBL7671960 | 0.83 | MAPT (0.64) | MAPTALDH1A1KDM4EL3MBTL1GAA | |
| SCHEMBL7853170 | 0.83 | MAPT (0.60) | MAPTALDH1A1KDM4EL3MBTL1GAA | |
| SCHEMBL8241650 | 0.82 | ALDH1A1 (0.85) | MAPTALDH1A1KDM4EL3MBTL1GAA | |
| SCHEMBL7678496 | 0.81 | MAPT (0.62) | MAPTALDH1A1KDM4EL3MBTL1GAA | |
| SCHEMBL7856733 | 0.81 | MAPT (0.64) | MAPTALDH1A1KDM4EL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6472418-B1 | Non-peptide NK1 receptors antagonists | WARNER-LAMBERT COMPANY | 2002-10-29 | — | — | US | disclosed |
| EP-1140914-A1 | NON-PEPTIDE NK1 RECEPTORS ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037462-A1 | NON-PEPTIDE NK1 RECEPTORS ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 2000-06-29 | — | — | WO | disclosed |