Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.60 |
| ▸ | HTR7 | P34969 | 4/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.48 |
| ▸ | EGFR | P00533 | 3/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7854266 | 0.87 | CDC42 (0.47) | MAPKAPK2SIRT1 | |
| SCHEMBL7851653 | 0.85 | MAPKAPK2 (0.62) | MAPKAPK2SIRT1 | |
| SCHEMBL7676904 | 0.84 | SIRT1 (0.43) | MAPKAPK2SIRT1SIRT2 | |
| SCHEMBL7680354 | 0.84 | HTR2A (0.47) | MAPKAPK2CYP2D6SIRT1 | |
| SCHEMBL7680308 | 0.84 | MAPKAPK2 (0.63) | MAPKAPK2SIRT1SIRT2 | |
| SCHEMBL7843811 | 0.84 | MAPKAPK2 (0.63) | MAPKAPK2BRD3 | |
| SCHEMBL7680950 | 0.84 | SIRT1 (0.54) | MAPKAPK2SIRT1SIRT2 | |
| Hydrochloric Acid SCHEMBL7673540 | 0.83 | HTR2A (0.49) | MAPKAPK2CYP2D6SIRT1 | |
| Hydrochloric Acid SCHEMBL7673537 | 0.83 | HTR2A (0.49) | MAPKAPK2CYP2D6SIRT1 | |
| Hydrochloric Acid SCHEMBL7678941 | 0.82 | MAPKAPK2 (0.48) | MAPKAPK2HTR7CYP3A4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350757-B1 | Beta-carboline compounds | LES LABORATOIRES SERVIER (FR) | 2002-02-26 | — | — | US | disclosed |
| EP-1070716-A1 | Beta-carboline derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2001-01-24 | — | — | EP | disclosed |