Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 7/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 7/20 | 0.39 |
| ▸ | HTR2C | P28335 | 7/20 | 0.39 |
| ▸ | HTR2B | P41595 | 4/20 | 0.39 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7680950 | 0.91 | SIRT1 (0.54) | SIRT1MAPKAPK2RECQLSIRT2HTR2A | |
| Hydrochloric Acid SCHEMBL7682863 | 0.86 | KMT2A (0.43) | SIRT1RECQLSIRT2KDM4EPSMD14 | |
| SCHEMBL7680833 | 0.84 | S1PR1 (0.41) | MAPKAPK2 | |
| SCHEMBL7676958 | 0.84 | MAPKAPK2 (0.60) | SIRT1MAPKAPK2SIRT2 | |
| SCHEMBL7852507 | 0.82 | MAPKAPK2 (0.45) | SIRT1MAPKAPK2HTR2AHTR2CHTR2B | |
| SCHEMBL7850754 | 0.82 | MAPKAPK2 (0.40) | SIRT1MAPKAPK2HTR2AHTR2CHTR2B | |
| SCHEMBL7855196 | 0.81 | MAPKAPK2 (0.54) | MAPKAPK2KDM4EPSMD14POLBGAA | |
| SCHEMBL7851653 | 0.81 | MAPKAPK2 (0.62) | SIRT1MAPKAPK2HTR2AHTR2C | |
| SCHEMBL7843811 | 0.80 | MAPKAPK2 (0.63) | MAPKAPK2HTR2AHTR2CHTR2B | |
| SCHEMBL7680308 | 0.80 | MAPKAPK2 (0.63) | SIRT1MAPKAPK2SIRT2HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350757-B1 | Beta-carboline compounds | LES LABORATOIRES SERVIER (FR) | 2002-02-26 | — | — | US | disclosed |
| EP-1070716-A1 | Beta-carboline derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2001-01-24 | — | — | EP | disclosed |