Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | TLR2 | O60603 | 1/20 | 0.39 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12172853 | 0.84 | POLB (0.45) | POLBCHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL13544590 | 0.83 | POLB (0.42) | POLBTAAR1TLR2TLR1KMT2A | |
| SCHEMBL5350167 | 0.82 | CHRNB2 (0.46) | POLBCHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL27000233 | 0.81 | GRM4 (0.56) | POLBGRM4TAAR1EPHX1ALDH1A1 | |
| SCHEMBL23729749 | 0.79 | CHRNB2 (0.44) | POLBCHRNB2CHRNB4CHRNA3CHRNA7 | |
| Butane SCHEMBL22499833 | 0.78 | GABRR1 (0.46) | POLBGRM4MEN1KMT2AKDM4E | |
| SCHEMBL23637868 | 0.78 | CHRNB2 (0.49) | POLBCHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL26212336 | 0.77 | CHRNB2 (0.53) | POLBCHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL10025661 | 0.77 | POLB (0.38) | POLBCHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL7687818 | 0.76 | POLB (0.37) | POLBTAAR1KMT2AGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441177-B1 | Tertiary amines | HOFFMANN-LA ROCHE INC. | 2002-08-27 | — | — | US | disclosed |
| US-6034275-A | FUGICIDES; ATICHOLESTEROL AGENTS | HOFFMANN-LA ROCHE INC. (US) | 2000-03-07 | — | — | US | disclosed |