Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 17/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pterin-6-Carboxylic Acid SCHEMBL893094 | 0.88 | AKR1B1 (0.56) | AKR1B1KDM4EALDH1A1LMNAGLA | |
| Pterin-6-Carboxylic Acid SCHEMBL17439631 | 0.86 | AKR1B1 (0.55) | AKR1B1KDM4EALDH1A1LMNAGLA | |
| SCHEMBL4297911 | 0.78 | KDM4E (0.46) | AKR1B1KDM4EALDH1A1LMNAGLA | |
| SCHEMBL7682920 | 0.76 | KDM4E (0.47) | AKR1B1KDM4EALDH1A1LMNAGLA | |
| SCHEMBL7677717 | 0.75 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL7677673 | 0.75 | ALDH1A1 (0.47) | AKR1B1KDM4EALDH1A1LMNAGLA | |
| SCHEMBL7683620 | 0.73 | KDM4E (0.45) | AKR1B1KDM4EALDH1A1LMNAGLA | |
| SCHEMBL4816470 | 0.72 | KDM4E (0.44) | AKR1B1KDM4EALDH1A1LMNAGLA | |
| Pterin-6-Carboxylic Acid SCHEMBL893092 | 0.72 | AKR1B1 (0.78) | AKR1B1HSD17B10 | |
| Pterin-6-Carboxylic Acid SCHEMBL31149841 | 0.72 | AKR1B1 (0.78) | AKR1B1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3102245-B1 | METHODS OF SCREENING, SELECTING, AND IDENTIFYING CYTOTOXIC RECOMBINANT POLYPEPTIDES BASED ON AN INTERIM DIMINUTION OF RIBOTOXICITY | MOLECULAR TEMPLATES INC (US) | 2021-09-08 | — | — | EP | disclosed |
| US-10421958-B2 | Methods of screening, selecting, and identifying cytotoxic recombinant polypeptides based on an interim diminution of ribotoxicity | MOLECULAR TEMPLATES, INC. (US) | 2019-09-24 | — | — | US | disclosed |
| EP-3102245-A2 | METHODS OF SCREENING, SELECTING, AND IDENTIFYING CYTOTOXIC RECOMBINANT POLYPEPTIDES BASED ON AN INTERIM DIMINUTION OF RIBOTOXICITY | Molecular Templates, Inc. (US) | 2016-12-14 | — | — | EP | disclosed |
| US-20160355803-A1 | METHODS OF SCREENING, SELECTING, AND IDENTIFYING CYTOTOXIC RECOMBINANT POLYPEPTIDES BASED ON AN INTERIM DIMINUTION OF RIBOTOXICITY | MOLECULAR TEMPLATES, INC. (US) | 2016-12-08 | — | — | US | disclosed |
| WO-2015120058-A9 | METHODS OF SCREENING, SELECTING, AND IDENTIFYING CYTOTOXIC RECOMBINANT POLYPEPTIDES BASED ON AN INTERIM DIMINUTION OF RIBOTOXICITY | MOLECULAR TEMPLATES, INC. (US) | 2016-06-02 | — | — | WO | disclosed |
| WO-2015120058-A2 | METHODS OF SCREENING, SELECTING, AND IDENTIFYING CYTOTOXIC RECOMBINANT POLYPEPTIDES BASED ON AN INTERIM DIMINUTION OF RIBOTOXICITY | MOLECULAR TEMPLATES, INC. (US) | 2015-08-13 | — | — | WO | disclosed |
| US-6358953-B1 | ADMINISTERING PTERIN METAL COMPLEX AS ANTICARCINOGENIC AGENTS AND VIRICIDES | Moheno, Phillip B. B. | 2002-03-19 | — | — | US | disclosed |
| EP-1123294-A1 | NOVEL PTERIN ANTINEOPLASTIC AGENTS | Moheno, Phillip B. B. (US) | 2001-08-16 | — | — | EP | disclosed |
| WO-2000023448-A1 | NOVEL PTERIN ANTINEOPLASTIC AGENTS | MOHENO PHILLIP B B (US) | 2000-04-27 | — | — | WO | disclosed |