Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 4/20 | 0.69 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.59 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.59 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.52 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.52 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4734973 | 0.88 | ERN1 (0.69) | ERN1MKNK1MKNK2CYP11B2CYP19A1 | |
| SCHEMBL32670810 | 0.82 | ALDH1A1 (0.68) | ERN1KDM4EHSD17B10ALDH1A1NPC1 | |
| SCHEMBL11871188 | 0.82 | ALDH1A1 (0.68) | ERN1KDM4EHSD17B10ALDH1A1NPC1 | |
| SCHEMBL12766984 | 0.82 | ERN1 (1.00) | ERN1 | |
| SCHEMBL6040671 | 0.81 | ERN1 (0.64) | ERN1MKNK1MKNK2CYP11B2CYP19A1 | |
| SCHEMBL11342031 | 0.81 | KDM4E (0.70) | ERN1MKNK1MKNK2CYP11B2CYP19A1 | |
| SCHEMBL29869842 | 0.81 | ALDH1A1 (0.58) | ERN1KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL30196133 | 0.81 | KDM4E (0.70) | ERN1MKNK1MKNK2CYP11B2CYP19A1 | |
| SCHEMBL505528 | 0.81 | ALDH1A1 (0.58) | ERN1KDM4EALDH1A1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL11336399 | 0.80 | KDM4E (0.68) | ERN1MKNK1MKNK2CYP11B2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020143011-A1 | Tri-substituted phenyl derivatives and processes for their preparation | CELLTECH THERAPEUTICS, LIMITED | 2002-10-03 | — | — | US | disclosed |
| US-6245774-B1 | ANTIINFLAMMATORY AGENTS; BRONCHODILATOR AGENTS | CELLTECH THERAPEUTICS LIMITED (GB) | 2001-06-12 | — | — | US | disclosed |
| EP-0766669-A1 | TRI-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-04-09 | — | — | EP | disclosed |
| WO-1995035283-A1 | TRI-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1995-12-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020143011-A1 | Tri-substituted phenyl derivatives and processes for their preparation | CBR1, NCOR1, CNR1 | ERN1 625/4885MKNK1 4405/4885MKNK2 4315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.