Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 6/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | RORA | P35398 | 1/20 | 0.37 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7677971 | 0.82 | F2 (0.46) | F2TRPA1ALDH1A1NLRP3 | |
| SCHEMBL7022618 | 0.82 | F2 (0.56) | F2TRPA1PRSS1PRSS2PRSS3 | |
| SCHEMBL7022614 | 0.82 | F2 (0.56) | F2TRPA1PRSS1PRSS2PRSS3 | |
| SCHEMBL7028108 | 0.74 | F2 (0.56) | F2TRPA1PRSS1PRSS2PRSS3 | |
| SCHEMBL7019506 | 0.71 | F2 (0.55) | F2TRPA1PRSS1PRSS2PRSS3 | |
| SCHEMBL7017912 | 0.71 | F2 (0.69) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7311268 | 0.66 | F2 (0.51) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7311273 | 0.66 | F2 (0.51) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7311846 | 0.66 | F2 (0.44) | F2TRPA1PRSS1PRSS2PRSS3 | |
| SCHEMBL9717422 | 0.66 | HDAC1 (0.51) | F2TRPA1KMT2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6417203-B1 | HETEROCYCLIC AMIDES | PFIZER INC. | 2002-07-09 | — | — | US | disclosed |