Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 8/20 | 0.53 |
| ▸ | DYRK1B | Q9Y463 | 7/20 | 0.53 |
| ▸ | DYRK2 | Q92630 | 4/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | PRKCI | P41743 | 1/20 | 0.47 |
| ▸ | CLK1 | P49759 | 5/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 3/20 | 0.45 |
| ▸ | CLK3 | P49761 | 2/20 | 0.45 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.45 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
| ▸ | ERN1 | O75460 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11981322 | 0.88 | DYRK1A (0.51) | DYRK1ADYRK1BDYRK2PIK3CAPRKCI | |
| SCHEMBL20558808 | 0.80 | DYRK1A (0.57) | DYRK1ADYRK1BDYRK2PIK3CAPRKCI | |
| SCHEMBL6349789 | 0.78 | DYRK1A (0.51) | DYRK1ADYRK1BDYRK2PIK3CACLK1 | |
| SCHEMBL6349783 | 0.78 | DYRK1A (0.51) | DYRK1ADYRK1BDYRK2PIK3CACLK1 | |
| SCHEMBL15965547 | 0.77 | DYRK1A (0.54) | DYRK1ADYRK1BDYRK2PIK3CAPRKCI | |
| SCHEMBL11981321 | 0.77 | CYP3A4 (0.56) | DYRK1ADYRK1BDYRK2PIK3CAPRKCI | |
| SCHEMBL4149733 | 0.77 | DYRK1A (0.57) | DYRK1ADYRK1BDYRK2PIK3CAPRKCI | |
| SCHEMBL339129 | 0.77 | DYRK1A (0.61) | DYRK1ADYRK1BDYRK2PIK3CAPRKCI | |
| SCHEMBL338477 | 0.76 | DYRK1A (0.47) | DYRK1ADYRK1BDYRK2PIK3CAPRKCI | |
| SCHEMBL2871514 | 0.76 | DYRK1A (0.47) | DYRK1ADYRK1BDYRK2PIK3CAPRKCI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020052509-A1 | Calcilytic compounds and method of use | SMITHKLINE BEECHAM CORPORATION | 2002-05-02 | — | — | US | disclosed |
| EP-1069901-A4 | CALCILYTIC COMPOUNDS AND METHOD OF USE | SMITHKLINE BEECHAM CORP (US) | 2001-06-13 | — | — | EP | disclosed |
| EP-1069901-A1 | CALCILYTIC COMPOUNDS AND METHOD OF USE | SMITHKLINE BEECHAM CORPORATION (US) | 2001-01-24 | — | — | EP | disclosed |
| WO-1999051241-A1 | CALCILYTIC COMPOUNDS AND METHOD OF USE | SMITHKLINE BEECHAM CORPORATION (US) | 1999-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020052509-A1 | Calcilytic compounds and method of use | SOST, CALCR, PTH1R | DYRK1A 3876/4885DYRK1B 3840/4885DYRK2 3396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.