Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.43 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7678123 | 0.93 | MAPK1 (0.46) | TSHRMAPK1L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7678134 | 0.93 | MAPK1 (0.46) | TSHRMAPK1L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL27559947 | 0.88 | L3MBTL1 (0.48) | TSHRMAPK1L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7683695 | 0.88 | KDM4E (0.52) | TSHRMAPK1ALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL21580836 | 0.83 | TSHR (0.51) | TSHRMAPK1L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9597051 | 0.83 | TSHR (0.51) | TSHRMAPK1L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL29848653 | 0.82 | SMN1; SMN2 (0.44) | TSHRMAPK1L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL21580855 | 0.82 | TSHR (0.47) | TSHRMAPK1L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL26961596 | 0.81 | MAPK1 (0.45) | MAPK1L3MBTL1ALDH1A1PKMMAPT | |
| SCHEMBL28107031 | 0.81 | TSHR (0.41) | TSHRMAPK1L3MBTL1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013093928-A1 | AN IMPROVED PROCESS FOR PREPARING 2-OXINDOLES OF FORMULA I, A KEY RAW MATERIAL FOR MAKING PHARMACEUTICAL DRUGS AND INTERMEDIATES THEREOF | ARCH PHARMALABS LIMITED (IN) | 2013-06-27 | — | — | WO | disclosed |
| US-6469181-B1 | PREPARING 2-OXINDOLES AND N-HYROXY-2- OXINDOLES VIA REDUCTION OF 2-NITROARYLMALONATE DIESTERS WITHOUT ISOLATION OF INTERMEDIATES | CATALYTICA, INC. | 2002-10-22 | — | — | US | disclosed |