Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7683699 | 0.93 | ALDH1A1 (0.49) | KDM4ESMN1; SMN2ALDH1A1KMT2ANPC1 | |
| SCHEMBL7683703 | 0.93 | ALDH1A1 (0.49) | KDM4ESMN1; SMN2ALDH1A1KMT2ANPC1 | |
| SCHEMBL29178312 | 0.88 | PDE7A (0.52) | KDM4ESMN1; SMN2ALDH1A1KMT2ANPC1 | |
| SCHEMBL27405293 | 0.88 | LMNA (0.51) | KDM4ESMN1; SMN2ALDH1A1KMT2ANPC1 | |
| SCHEMBL7678122 | 0.88 | TSHR (0.50) | KDM4ESMN1; SMN2ALDH1A1KMT2ANPC1 | |
| SCHEMBL27633813 | 0.83 | SMN1; SMN2 (0.54) | KDM4ESMN1; SMN2ALDH1A1KMT2ANPC1 | |
| SCHEMBL11644003 | 0.82 | SMN1; SMN2 (0.51) | KDM4ESMN1; SMN2ALDH1A1KMT2ANPC1 | |
| SCHEMBL27677809 | 0.81 | SMN1; SMN2 (0.48) | KDM4ESMN1; SMN2ALDH1A1KMT2ANPC1 | |
| SCHEMBL7674664 | 0.81 | ABCB1 (0.43) | KDM4EALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL7678123 | 0.81 | MAPK1 (0.46) | SMN1; SMN2ALDH1A1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6469181-B1 | PREPARING 2-OXINDOLES AND N-HYROXY-2- OXINDOLES VIA REDUCTION OF 2-NITROARYLMALONATE DIESTERS WITHOUT ISOLATION OF INTERMEDIATES | CATALYTICA, INC. | 2002-10-22 | — | — | US | disclosed |
| EP-0809631-A4 | PROCESS FOR PREPARING 2-OXINDOLES AND N-HYDROXY-2-OXINDOLES | CATALYTICA INC (US) | 1998-07-08 | — | — | EP | disclosed |
| EP-0809631-A1 | PROCESS FOR PREPARING 2-OXINDOLES AND N-HYDROXY-2-OXINDOLES | CATALYTICA, INC. (US) | 1997-12-03 | — | — | EP | disclosed |
| WO-1996023770-A1 | PROCESS FOR PREPARING 2-OXINDOLES AND N-HYDROXY-2-OXINDOLES | CATALYTICA, INC. (US) | 1996-08-08 | — | — | WO | disclosed |