Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL469817 | 0.86 | KDM4E (0.51) | KDM4EMAPTCYP1A2BRD4ALOX15 | |
| SCHEMBL22534128 | 0.85 | KDM4E (0.50) | KDM4EMAPTCYP1A2BRD4ALOX15 | |
| SCHEMBL13977549 | 0.84 | BRD4 (0.50) | KDM4EMAPTCYP1A2BRD4ALOX15 | |
| SCHEMBL31672530 | 0.73 | KDM4E (0.50) | KDM4EMAPTALDH1A1HPGDMAPK1 | |
| SCHEMBL16595631 | 0.73 | KDM4E (0.43) | KDM4EMAPTBRD4ALOX15HSD17B10 | |
| SCHEMBL29282052 | 0.67 | KDM4E (0.44) | KDM4EMAPTCYP1A2BRD4ALOX15 | |
| SCHEMBL19318769 | 0.66 | ALOX15 (0.45) | KDM4EMAPTCYP1A2BRD4ALOX15 | |
| SCHEMBL24608876 | 0.66 | KDM4E (0.34) | KDM4EMAPTALOX15RAB9AMEN1 | |
| SCHEMBL30360042 | 0.66 | MAPT (0.36) | KDM4EMAPTBRD4ALOX15HSD17B10 | |
| SCHEMBL15221347 | 0.65 | GRM1 (0.40) | KDM4EMAPTCYP1A2BRD4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255752-A2 | PYRROLE SUBSTITUTED 2-INDOLINONE PROTEIN KINASE INHIBITORS | Sugen, Inc. (US) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001060814-A2 | PYRROLE SUBSTITUTED 2-INDOLINONE PROTEIN KINASE INHIBITORS | SUGEN, INC. (US) | 2001-08-23 | — | — | WO | disclosed |