SCHEMBL469817

SCHEMBL469817

CCOC(=O)c1[nH]cc2c1CCCC2

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.51
MAPT P10636 4/20 0.51
BRD4 O60885 1/20 0.47
LMNA P02545 1/20 0.43
MEN1 O00255 2/20 0.42
RAB9A P51151 2/20 0.42
KMT2A Q03164 2/20 0.42
NPC1 O15118 1/20 0.42
ALOX15 P16050 3/20 0.41
HSD17B10 Q99714 3/20 0.41
ALDH1A1 P00352 2/20 0.41
HPGD P15428 2/20 0.41
GAA P10253 1/20 0.41
MAPK1 P28482 1/20 0.41
CYP1A2 P05177 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
NLRP3 Q96P20 4/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22534128 0.98 KDM4E (0.50) KDM4EMAPTBRD4LMNAMEN1
SCHEMBL13977549 0.97 BRD4 (0.50) KDM4EMAPTBRD4LMNAMEN1
SCHEMBL7678336 0.86 KDM4E (0.42) KDM4EMAPTBRD4LMNAMEN1
SCHEMBL16595631 0.85 KDM4E (0.43) KDM4EMAPTBRD4LMNAMEN1
SCHEMBL16595639 0.82 USP2 (0.39) KDM4EMAPTRAB9AKMT2ANPC1
SCHEMBL29282052 0.78 KDM4E (0.44) KDM4EMAPTBRD4MEN1KMT2A
SCHEMBL19318769 0.77 ALOX15 (0.45) KDM4EMAPTBRD4LMNAMEN1
SCHEMBL24608876 0.76 KDM4E (0.34) KDM4EMAPTMEN1RAB9AKMT2A
SCHEMBL15221347 0.76 GRM1 (0.40) KDM4EMAPTBRD4LMNAMEN1
SCHEMBL21579187 0.75 ALDH1A1 (0.44) KDM4ELMNAMEN1RAB9AKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113748184-B Boron-containing cyclic light-emitting compound and color conversion film containing same 日东电工株式会社 2025-04-04 CN disclosed
CN-115335488-A Boron-containing cyclic luminescent compound and color conversion film comprising the same 日东电工株式会社 2022-11-11 CN disclosed
US-20220216411-A1 BORON-CONTAINING CYCLIC EMISSIVE COMPOUNDS AND COLOR CONVERSION FILM CONTAINING THE SAME NITTO DENKO CORP (JP) 2022-07-07 US disclosed
US-20220216411-A1 BORON-CONTAINING CYCLIC EMISSIVE COMPOUNDS AND COLOR CONVERSION FILM CONTAINING THE SAME NITTO DENKO CORP (JP) 2022-07-07 US disclosed
WO-2021188762-A1 BORON-CONTAINING CYCLIC EMISSIVE COMPOUNDS AND COLOR CONVERSION FILM CONTAINING THE SAME NITTO DENKO CORPORATION (JP) 2021-09-23 WO disclosed
US-20210093239-A1 OXYGEN SENSORS PROFUSA, INC. (US) 2021-04-01 US disclosed
EP-3797798-A1 OXYGEN SENSORS Profusa, Inc. (US) 2021-03-31 EP disclosed
US-10874337-B2 Oxygen sensors PROFUSA, INC. (US) 2020-12-29 US disclosed
WO-2020210761-A1 BORON-CONTAINING CYCLIC EMISSIVE COMPOUNDS AND COLOR CONVERSION FILM CONTAINING THE SAME NITTO DENKO CORPORATION (JP) 2020-10-15 WO disclosed
WO-2020210761-A1 BORON-CONTAINING CYCLIC EMISSIVE COMPOUNDS AND COLOR CONVERSION FILM CONTAINING THE SAME NITTO DENKO CORPORATION (JP) 2020-10-15 WO disclosed
US-20050176802-A1 Pyrrole substituted 2-indolinone protein kinase inhibitors SUGEN, INC. & PHARMACIA & UPJOHN CO. 2005-08-11 US disclosed
WO-2005066135-A2 PYRROLE AND PYRAZOLE DAAO INHIBITORS SEPRACOR INC. (US) 2005-07-21 WO disclosed
US-20050143443-A1 Pyrrole and pyrazole DAAO inhibitors SEPRACOR INC. (US) 2005-06-30 US disclosed
US-6878733-B1 Formulations for pharmaceutical agents ionizable as free acids or free bases SUGEN, INC. (US) 2005-04-12 US disclosed
US-20040063773-A1 Pyrrole substituted 2-indolinone protein kinase inhibitors SUGEN, INC. & PHARMACIA & UPJOHN CO. 2004-04-01 US disclosed
US-20030216410-A1 Combination therapy for the treatment of cancer PHARMACIA CORPORATION 2003-11-20 US disclosed
US-6573293-B2 Pyrrole substituted 2-indolinone protein kinase inhibitors SUGEN, INC. 2003-06-03 US disclosed
US-20020156292-A1 Pyrrole substituted 2-indolinone protein kinase inhibitors PHARMACIA & UPJOHN COMPANY LLC 2002-10-24 US disclosed
EP-1233943-A2 IONIZABLE INDOLINONE DERIVATIVES AND THEIR USE AS PTK LIGANDS Sugen, Inc. (US) 2002-08-28 EP disclosed
WO-2001037820-A2 IONIZABLE INDOLINONE DERIVATIVES AND THEIR USE AS PTK LIGANDS SUGEN, INC. (US) 2001-05-31 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030216410-A1 Combination therapy for the treatment of cancer PTGS2, PTGES2, PTGFR KDM4E 2807/4885MAPT 4505/4885BRD4 1108/4885
US-20220216411-A1 BORON-CONTAINING CYCLIC EMISSIVE COMPOUNDS AND COLOR CONVERSION FILM CONTAINING THE SAME BLVRB, CLTB, CRY1 KDM4E 1084/4885MAPT 497/4885BRD4 68/4885
US-20050176802-A1 Pyrrole substituted 2-indolinone protein kinase inhibitors PDPK1, MAP3K20, PLK2 KDM4E 1307/4885MAPT 1881/4885BRD4 695/4885
US-20210093239-A1 OXYGEN SENSORS COXFA4L2, PPOX, EGLN3 KDM4E 2173/4885MAPT 3747/4885BRD4 3249/4885
US-20050143443-A1 Pyrrole and pyrazole DAAO inhibitors DDO, DAO, SRR KDM4E 1764/4885MAPT 1403/4885BRD4 1860/4885
US-10874337-B2 Oxygen sensors COXFA4L2, PPOX, EGLN3 KDM4E 2173/4885MAPT 3747/4885BRD4 3249/4885
US-20040063773-A1 Pyrrole substituted 2-indolinone protein kinase inhibitors PDPK1, MAP3K20, PLK2 KDM4E 1307/4885MAPT 1881/4885BRD4 695/4885
US-20020156292-A1 Pyrrole substituted 2-indolinone protein kinase inhibitors PDPK1, MAP3K20, PLK2 KDM4E 1307/4885MAPT 1881/4885BRD4 695/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.