Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MPI | P34949 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7681827 | 0.87 | PIK3CA (0.47) | PIK3CAALDH1A1KDM4EHCRTR1HCRTR2 | |
| SCHEMBL7673351 | 0.81 | HRH3 (0.46) | PIK3CAALDH1A1KDM4EOPRM1OPRL1 | |
| SCHEMBL3742630 | 0.81 | PIK3CA (0.57) | PIK3CAABL1LRRK2 | |
| SCHEMBL7673438 | 0.78 | PIK3CA (0.46) | PIK3CAALDH1A1TBK1HCRTR1HCRTR2 | |
| SCHEMBL7675387 | 0.76 | PIK3CA (0.44) | PIK3CAALDH1A1KDM4ETBK1HCRTR1 | |
| SCHEMBL8197483 | 0.75 | PIK3CA (0.59) | PIK3CAHCRTR1HCRTR2OPRM1OPRL1 | |
| SCHEMBL8358064 | 0.75 | PIK3CA (0.54) | PIK3CAABL1HCRTR1HCRTR2OPRM1 | |
| SCHEMBL5718308 | 0.75 | PIK3CA (0.54) | PIK3CAABL1HCRTR1HCRTR2OPRM1 | |
| SCHEMBL2459118 | 0.75 | PIK3CA (0.54) | PIK3CAABL1HCRTR1HCRTR2OPRM1 | |
| SCHEMBL7681152 | 0.74 | CYP2D6 (0.55) | PIK3CAALDH1A1KDM4ELMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6455520-B1 | TUMOR NECROSIS FACTOR AND INTERLEUKIN INHIBITORS; ANTIINFLAMMATORY AGENTS, ANTIALLERGENS; BONE DISORDERS | ASTRA ZENECA AB (SE) | 2002-09-24 | — | — | US | disclosed |