Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.45 |
| ▸ | CHKA | P35790 | 1/20 | 0.43 |
| ▸ | ATR | Q13535 | 1/20 | 0.43 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MC4R | P32245 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7678396 | 0.87 | PIK3CA (0.48) | PIK3CAALDH1A1OPRM1OPRL1LRRK2 | |
| SCHEMBL7673351 | 0.86 | HRH3 (0.46) | PIK3CAALDH1A1OPRM1OPRL1LRRK2 | |
| SCHEMBL7675387 | 0.81 | PIK3CA (0.44) | PIK3CAALDH1A1OPRM1OPRL1LRRK2 | |
| SCHEMBL8197483 | 0.80 | PIK3CA (0.59) | PIK3CAOPRM1OPRL1LRRK2HCRTR1 | |
| SCHEMBL2370607 | 0.77 | HRH4 (0.52) | HRH4HRH3NPSR1 | |
| SCHEMBL13069962 | 0.77 | PIK3CA (0.53) | PIK3CAALDH1A1OPRM1OPRL1LRRK2 | |
| SCHEMBL7673438 | 0.77 | PIK3CA (0.46) | PIK3CAALDH1A1OPRM1OPRL1ATR | |
| SCHEMBL8358064 | 0.77 | PIK3CA (0.54) | PIK3CAOPRM1OPRL1LRRK2HCRTR1 | |
| SCHEMBL2459118 | 0.77 | PIK3CA (0.54) | PIK3CAOPRM1OPRL1LRRK2HCRTR1 | |
| SCHEMBL5718308 | 0.77 | PIK3CA (0.54) | PIK3CAOPRM1OPRL1LRRK2HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6455520-B1 | TUMOR NECROSIS FACTOR AND INTERLEUKIN INHIBITORS; ANTIINFLAMMATORY AGENTS, ANTIALLERGENS; BONE DISORDERS | ASTRA ZENECA AB (SE) | 2002-09-24 | — | — | US | disclosed |