Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28958552 | 0.69 | KDM4E (0.48) | MAPTKDM4ENPC1RAB9ACYP1A2 | |
| SCHEMBL1757222 | 0.64 | ALDH1A1 (0.60) | GAAMAPTKDM4ENPC1RAB9A | |
| SCHEMBL1257007 | 0.64 | MAPT (0.50) | GAAMAPTKDM4ENPC1RAB9A | |
| SCHEMBL8630260 | 0.64 | TSHR (0.52) | GAAMAPTKDM4ENPC1RAB9A | |
| SCHEMBL19084410 | 0.63 | TSHR (0.46) | MAPTKDM4ENPC1RAB9ACYP1A2 | |
| SCHEMBL17223287 | 0.63 | TSHR (0.55) | GAAMAPTKDM4ENPC1RAB9A | |
| SCHEMBL28479419 | 0.63 | TSHR (0.46) | GAAMAPTKDM4ENPC1RAB9A | |
| SCHEMBL158238 | 0.63 | TSHR (0.55) | GAAMAPTKDM4ECYP1A2TSHR | |
| SCHEMBL3185303 | 0.62 | MAPT (0.39) | GAAMAPTKDM4ENPC1RAB9A | |
| SCHEMBL6336946 | 0.62 | TSHR (0.44) | MAPTKDM4ENPC1RAB9ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6479527-B1 | Bicyclic pyrrole derivatives as MCP-1 inhibitors | ASTRAZENECA UK LIMITED (GB) | 2002-11-12 | — | — | US | disclosed |