Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | GFER | P55789 | 1/20 | 0.64 |
| ▸ | HTR2A | P28223 | 4/20 | 0.61 |
| ▸ | HTR2C | P28335 | 4/20 | 0.61 |
| ▸ | HTR2B | P41595 | 4/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | ABHD6 | Q9BV23 | 3/20 | 0.38 |
| ▸ | XIAP | P98170 | 2/20 | 0.36 |
| ▸ | BIRC2 | Q13490 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7673512 | 0.85 | HTR2A (0.61) | LMNAPMP22NPSR1GFERHTR2A | |
| SCHEMBL7676422 | 0.81 | LMNA (0.43) | LMNAPMP22NPSR1GFERHTR2A | |
| SCHEMBL7674586 | 0.76 | HTR2A (1.00) | LMNAPMP22NPSR1GFERHTR2A | |
| SCHEMBL29462310 | 0.76 | HTR2A (1.00) | LMNAPMP22NPSR1GFERHTR2A | |
| SCHEMBL905755 | 0.76 | HTR2A (1.00) | LMNAPMP22NPSR1GFERHTR2A | |
| SCHEMBL7679545 | 0.74 | LMNA (0.65) | LMNAPMP22NPSR1GFERHTR2A | |
| SCHEMBL7997579 | 0.74 | LMNA (0.43) | LMNAPMP22NPSR1GFERHTR2A | |
| Fumaric Acid SCHEMBL7679552 | 0.72 | LMNA (0.70) | LMNAPMP22NPSR1GFERHTR2A | |
| SCHEMBL7832484 | 0.71 | HTR2A (0.55) | LMNAPMP22NPSR1GFERHTR2A | |
| SCHEMBL7832870 | 0.71 | LMNA (0.45) | LMNAPMP22NPSR1GFERHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380238-B1 | FOR THERAPY OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM; DAMAGE TO THE CENTRAL NERVOUS SYSTEM; CARDIOVASCULAR DISORDERS; GASTROINTESTINAL DISORDERS; DIABETES INSIPIDUS, AND SLEEP APNEA | VERNALIS RESEARCH LIMITED (GB) | 2002-04-30 | — | — | US | disclosed |
| EP-1109784-A1 | INDOLINE DERIVATIVES AS 5-HT2B AND/OR 5-HT2C RECEPTOR LIGANDS | VERNALIS RESEARCH LIMITED (GB) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000012475-A1 | INDOLINE DERIVATIVES AS 5-HT2B AND/OR 5-HT2C RECEPTOR LIGANDS | VERNALIS RESEARCH LIMITED (GB) | 2000-03-09 | — | — | WO | disclosed |