Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | HTR2C | P28335 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7679840 | 1.00 | KMO (0.46) | KMOHTR2AHTR2CSMN1; SMN2KDM4E | |
| SCHEMBL8904901 | 0.84 | HTR2C (0.56) | HTR2AHTR2CKDM4EALDH1A1HPGD | |
| SCHEMBL1435876 | 0.82 | MTNR1A (0.44) | HTR2CSMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL1435874 | 0.82 | MTNR1A (0.44) | HTR2CSMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL7674622 | 0.79 | HTR2C (0.43) | HTR2AHTR2CSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7674627 | 0.79 | HTR2C (0.43) | HTR2AHTR2CSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7671707 | 0.79 | KMO (0.54) | KMOSMN1; SMN2MAPTBRD4 | |
| SCHEMBL7677110 | 0.78 | HTR2C (0.42) | HTR2AHTR2CSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7677108 | 0.78 | HTR2C (0.42) | HTR2AHTR2CSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL24110639 | 0.77 | FLT1 (0.42) | HTR2AHTR2CTRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380238-B1 | FOR THERAPY OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM; DAMAGE TO THE CENTRAL NERVOUS SYSTEM; CARDIOVASCULAR DISORDERS; GASTROINTESTINAL DISORDERS; DIABETES INSIPIDUS, AND SLEEP APNEA | VERNALIS RESEARCH LIMITED (GB) | 2002-04-30 | — | — | US | disclosed |