Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | GRM8 | O00222 | 1/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7680328 | 1.00 | ALDH1A1 (0.46) | ALDH1A1GPR35CYP1A2GRM8GRM4 | |
| SCHEMBL19210852 | 0.81 | ALDH1A1 (0.60) | ALDH1A1MEN1KMT2ATSHRHPGD | |
| SCHEMBL29444506 | 0.81 | ALDH1A1 (0.60) | ALDH1A1MEN1KMT2ATSHRHPGD | |
| SCHEMBL4076713 | 0.80 | GPR35 (0.44) | ALDH1A1GPR35CYP1A2GRM8GRM4 | |
| SCHEMBL4076707 | 0.80 | GPR35 (0.44) | ALDH1A1GPR35CYP1A2GRM8GRM4 | |
| SCHEMBL28768690 | 0.79 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2ATDP1TSHR | |
| SCHEMBL27783994 | 0.79 | HPGD (0.47) | ALDH1A1GPR35MEN1KMT2ATDP1 | |
| SCHEMBL8135421 | 0.79 | GPR35 (0.50) | ALDH1A1GPR35CYP1A2GRM8GRM4 | |
| SCHEMBL8135423 | 0.79 | GPR35 (0.50) | ALDH1A1GPR35CYP1A2GRM8GRM4 | |
| SCHEMBL27760563 | 0.79 | ALDH1A1 (0.51) | ALDH1A1GPR35MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6469181-B1 | PREPARING 2-OXINDOLES AND N-HYROXY-2- OXINDOLES VIA REDUCTION OF 2-NITROARYLMALONATE DIESTERS WITHOUT ISOLATION OF INTERMEDIATES | CATALYTICA, INC. | 2002-10-22 | — | — | US | disclosed |
| EP-0809631-A4 | PROCESS FOR PREPARING 2-OXINDOLES AND N-HYDROXY-2-OXINDOLES | CATALYTICA INC (US) | 1998-07-08 | — | — | EP | disclosed |
| EP-0809631-A1 | PROCESS FOR PREPARING 2-OXINDOLES AND N-HYDROXY-2-OXINDOLES | CATALYTICA, INC. (US) | 1997-12-03 | — | — | EP | disclosed |
| WO-1996023770-A1 | PROCESS FOR PREPARING 2-OXINDOLES AND N-HYDROXY-2-OXINDOLES | CATALYTICA, INC. (US) | 1996-08-08 | — | — | WO | disclosed |