Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | ELANE | P08246 | 2/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.46 |
| ▸ | PTGES | O14684 | 4/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6979378 | 0.87 | LMNA (0.59) | LMNASMN1; SMN2MAPTHTTTSHR | |
| SCHEMBL7846258 | 0.87 | LMNA (0.59) | LMNASMN1; SMN2MAPTHTTTSHR | |
| SCHEMBL6971418 | 0.87 | LMNA (0.54) | LMNASMN1; SMN2MAPTHTTTSHR | |
| SCHEMBL6975246 | 0.86 | LMNA (0.54) | LMNASMN1; SMN2MAPTHTTTSHR | |
| SCHEMBL6970992 | 0.83 | LMNA (0.54) | LMNASMN1; SMN2MAPTHTTTSHR | |
| SCHEMBL6976210 | 0.83 | LMNA (0.54) | LMNASMN1; SMN2MAPTHTTTSHR | |
| SCHEMBL6978779 | 0.83 | OPRK1 (0.56) | LMNASMN1; SMN2MAPTHTTTSHR | |
| SCHEMBL27495903 | 0.83 | LMNA (0.52) | LMNASMN1; SMN2MAPTHTTTSHR | |
| SCHEMBL6968264 | 0.83 | OPRK1 (0.56) | LMNASMN1; SMN2MAPTHTTTSHR | |
| SCHEMBL6972771 | 0.83 | SMN1; SMN2 (0.48) | LMNASMN1; SMN2MAPTHTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6372736-B1 | ENZYME INHIBITORS | PFIZER INC | 2002-04-16 | — | — | US | disclosed |
| EP-1100797-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | Pfizer Limited (GB) | 2001-05-23 | — | — | EP | disclosed |
| WO-2000005232-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER LIMITED (GB) | 2000-02-03 | — | — | WO | disclosed |