Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.46 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370447 | 0.84 | MAPK8 (0.56) | MAPK8HPGDKMT2ALMNASMN1; SMN2 | |
| SCHEMBL7370567 | 0.82 | MAPK8 (0.56) | MAPK8HPGDKMT2ALMNASMN1; SMN2 | |
| SCHEMBL7373102 | 0.80 | MAPK8 (0.53) | MAPK8HPGDKMT2ALMNASMN1; SMN2 | |
| SCHEMBL5608301 | 0.80 | PDE4A (0.48) | MAPK8HPGDKMT2ALMNASMN1; SMN2 | |
| SCHEMBL6579096 | 0.80 | ALDH1A1 (0.50) | MAPK8PTGER4PTGER2ADRA2AADRA2B | |
| SCHEMBL7365059 | 0.78 | MAPK8 (0.58) | MAPK8HPGDKMT2ALMNASMN1; SMN2 | |
| SCHEMBL7374630 | 0.78 | MAPK8 (0.58) | MAPK8HPGDKMT2ALMNASMN1; SMN2 | |
| SCHEMBL7365065 | 0.78 | MAPK8 (0.58) | MAPK8HPGDKMT2ALMNASMN1; SMN2 | |
| SCHEMBL7370275 | 0.78 | MAPK8 (0.49) | MAPK8HPGDKMT2AADRA2AADRA2B | |
| SCHEMBL7365372 | 0.77 | MAPK8 (0.74) | MAPK8KMT2AADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |