Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.48 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5362007 | 0.85 | HCRTR1 (0.49) | ALDH1A1MAPK8ADRA2AADRA2BADRA2C | |
| SCHEMBL10967980 | 0.82 | KMT2A (0.71) | ADRA2AADRA2BADRA2CGRM5 | |
| SCHEMBL6773056 | 0.82 | F10 (0.67) | PTGER4PTGER2GRM5F10 | |
| SCHEMBL7370275 | 0.82 | MAPK8 (0.49) | ALDH1A1MAPK8ADRA2AADRA2BADRA2C | |
| SCHEMBL7373877 | 0.81 | ELANE (0.53) | ALDH1A1TDP1HCRTR1HCRTR2F10 | |
| SCHEMBL7365372 | 0.81 | MAPK8 (0.74) | ALDH1A1MAPK8ADRA2AADRA2BADRA2C | |
| SCHEMBL7370447 | 0.81 | MAPK8 (0.56) | MAPK8ADRA2AADRA2BADRA2C | |
| SCHEMBL8568262 | 0.81 | ALDH1A1 (0.74) | ALDH1A1MAPK8TDP1POLBGAA | |
| SCHEMBL7373146 | 0.80 | MAPK8 (0.50) | ALDH1A1MAPK8ADRA2AADRA2BADRA2C | |
| SCHEMBL7680876 | 0.80 | MAPK8 (0.54) | MAPK8ADRA2AADRA2BADRA2CPTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0813525-B9 | BENZAMIDINE DERIVATIVES THEIR PREPARATION AND THEIR USE AS ANTI-COAGULANTS | BERLEX LAB (US) | 2004-02-04 | — | — | EP | disclosed |
| EP-0813525-B1 | BENZAMIDINE DERIVATIVES THEIR PREPARATION AND THEIR USE AS ANTI-COAGULANTS | BERLEX LAB (US) | 2003-10-01 | — | — | EP | disclosed |