Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 19/20 | 0.81 |
| ▸ | ROCK2 | O75116 | 18/20 | 0.81 |
| ▸ | SGK1 | O00141 | 1/20 | 0.61 |
| ▸ | AKT1 | P31749 | 1/20 | 0.61 |
| ▸ | GSK3B | P49841 | 1/20 | 0.61 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.61 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.61 |
| ▸ | DMPK | Q09013 | 1/20 | 0.61 |
| ▸ | MYLK | Q15746 | 1/20 | 0.61 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2554347 | 0.89 | ROCK1 (1.00) | ROCK1ROCK2SGK1AKT1GSK3B | |
| SCHEMBL2753297 | 0.79 | ALDH1A1 (0.67) | MEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL2557785 | 0.79 | ROCK1 (1.00) | ROCK1ROCK2 | |
| SCHEMBL2561226 | 0.79 | ROCK1 (0.81) | ROCK1ROCK2SGK1AKT1GSK3B | |
| SCHEMBL23352214 | 0.78 | ROCK1 (0.85) | ROCK1ROCK2SGK1AKT1GSK3B | |
| SCHEMBL2560201 | 0.78 | ROCK1 (1.00) | ROCK1ROCK2SGK1AKT1GSK3B | |
| SCHEMBL29431307 | 0.78 | ROCK1 (1.00) | ROCK1ROCK2SGK1AKT1GSK3B | |
| Hydrochloric Acid SCHEMBL17836965 | 0.77 | ROCK1 (0.98) | ROCK1ROCK2SGK1AKT1GSK3B | |
| Hydrochloric Acid SCHEMBL29633094 | 0.77 | ROCK1 (0.98) | ROCK1ROCK2SGK1AKT1GSK3B | |
| SCHEMBL2559909 | 0.77 | ROCK1 (1.00) | ROCK1ROCK2SGK1AKT1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6410533-B1 | THERAPY FOR BACTERIA INFECTIONS | GENZYME CORPORATION | 2002-06-25 | — | — | US | disclosed |