Hydrochloric Acid

Hydrochloric Acid

SCHEMBL17836965

Cl.Cl.O=C(NCc1cccc(O)c1)Nc1nc(-c2ccncc2)cs1

nearest known ligand 0.98

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ROCK1 known ✓ Q13464 20/20 0.98
ROCK2 known ✓ O75116 18/20 0.98
SGK1 O00141 1/20 0.88
AKT1 P31749 1/20 0.88
GSK3B P49841 1/20 0.88
LIMK1 P53667 1/20 0.88
TNK2 Q07912 1/20 0.88
DMPK Q09013 1/20 0.88
MYLK Q15746 1/20 0.88
CDC42BPA Q5VT25 1/20 0.88
PRKACA P17612 1/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL29633094 1.00 ROCK1 (0.98) ROCK1ROCK2SGK1AKT1GSK3B
SCHEMBL29431307 0.99 ROCK1 (1.00) ROCK1ROCK2SGK1AKT1GSK3B
SCHEMBL2560201 0.99 ROCK1 (1.00) ROCK1ROCK2SGK1AKT1GSK3B
SCHEMBL2551860 0.94 ROCK1 (1.00) ROCK1ROCK2SGK1AKT1GSK3B
SCHEMBL23352214 0.91 ROCK1 (0.85) ROCK1ROCK2SGK1AKT1GSK3B
SCHEMBL2554347 0.87 ROCK1 (1.00) ROCK1ROCK2SGK1AKT1GSK3B
SCHEMBL2555028 0.87 ROCK1 (1.00) ROCK1ROCK2SGK1AKT1GSK3B
SCHEMBL2560469 0.87 ROCK2 (1.00) ROCK1ROCK2SGK1AKT1GSK3B
SCHEMBL2559909 0.87 ROCK1 (1.00) ROCK1ROCK2SGK1AKT1GSK3B
SCHEMBL2557781 0.86 ROCK1 (1.00) ROCK1ROCK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200140827-A1 A SUBSTRATE AND METHOD FOR THE GENERATION OF INDUCED PLURIPOTENT STEM CELLS THE QUEEN'S UNIVERSITY OF BELFAST (GB) 2020-05-07 US claimed
EP-3630953-A1 A SUBSTRATE AND METHOD FOR THE GENERATION OF INDUCED PLURIPOTENT STEM CELLS The Queen's University Of Belfast (GB) 2020-04-08 EP claimed
WO-2018220081-A1 A SUBSTRATE AND METHOD FOR THE GENERATION OF INDUCED PLURIPOTENT STEM CELLS THE QUEEN'S UNIVERSITY OF BELFAST (GB) 2018-12-06 WO claimed
US-12618830-B2 Methods, culture medias and devices for generating embryos in vitro from stem cells CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2026-05-05 US disclosed
US-20260062678-A1 CELL REPLACEMENT THERAPY FOR PULMONARY DISEASES THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2026-03-05 US disclosed
EP-3680325-B1 PLATELET PRODUCTION METHOD, PLATELET PREPARATION PRODUCTION METHOD, AND BLOOD PREPARATION PRODUCTION METHOD MEGAKARYON CORP (JP) 2026-02-18 EP disclosed
US-12467917-B2 Reconstructing human early embryogenesis in vitro with pluripotent stem cells CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2025-11-11 US disclosed
EP-4581131-A1 DIFFERENTIAL ADHESION AND TENSION GUIDED FORMATION OF STEM CELL DERIVED EMBRYOS California Institute of Technology (US) 2025-07-09 EP disclosed
EP-4581130-A1 METHODS AND CULTURE MEDIA FOR GENERATING EMBRYOS IN VITRO FROM PLURIPOTENT STEM CELLS California Institute of Technology (US) 2025-07-09 EP disclosed
EP-4573186-A1 CELL COMPOSITIONS AND METHODS OF USING THE SAME THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-06-25 EP disclosed
US-20250114470-A1 THERAPY FOR POLYCYSTIC KIDNEY DISEASE UNIVERSITY OF MASSACHUSETTS 2025-04-10 US disclosed
EP-3630953-A1 A SUBSTRATE AND METHOD FOR THE GENERATION OF INDUCED PLURIPOTENT STEM CELLS The Queen's University Of Belfast (GB) 2020-04-08 EP disclosed
WO-2019217429-A1 LUNG AND AIRWAY PROGENITORS GENERATED FROM HUMAN PLURIPOTENT STEM CELLS AND RELATED TREATMENTS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2019-11-14 WO disclosed
US-20190338250-A1 METHODS FOR GENERATING STEM CELL-DERIVED BETA CELLS AND METHODS OF USE THEREOF HOWARD HUGHES MEDICAL INSTITUTE 2019-11-07 US disclosed
US-10443042-B2 Serum-free in vitro directed differentiation protocol for generating stem cell-derived beta cells and uses thereof PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2019-10-15 US disclosed
US-10253298-B2 Methods for generating stem cell-derived beta cells and methods of use thereof PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2019-04-09 US disclosed
WO-2019059234-A1 PLATELET PRODUCTION METHOD, PLATELET PREPARATION PRODUCTION METHOD, AND BLOOD PREPARATION PRODUCTION METHOD 株式会社メガカリオン 2019-03-28 WO disclosed
WO-2018220081-A1 A SUBSTRATE AND METHOD FOR THE GENERATION OF INDUCED PLURIPOTENT STEM CELLS THE QUEEN'S UNIVERSITY OF BELFAST (GB) 2018-12-06 WO disclosed
US-20160177267-A1 SERUM-FREE IN VITRO DIRECTED DIFFERENTIATION PROTOCOL FOR GENERATING STEM CELL-DERIVED BETA CELLS AND USES THEREOF HOWARD HUGHES MEDICAL INSTITUTE 2016-06-23 US disclosed
US-20160177269-A1 METHODS FOR GENERATING STEM CELL-DERIVED BETA CELLS AND METHODS OF USE THEREOF HOWARD HUGHES MEDICAL INSTITUTE 2016-06-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10253298-B2 Methods for generating stem cell-derived beta cells and methods of use thereof IAPP, RNASE1, PNLIP ROCK1 2444/4885ROCK2 2425/4885SGK1 2687/4885
US-20260062678-A1 CELL REPLACEMENT THERAPY FOR PULMONARY DISEASES WNT3A, BMP4, GSK3B ROCK1 12/4885ROCK2 14/4885SGK1 262/4885
US-12618830-B2 Methods, culture medias and devices for generating embryos in vitro from stem cells POU2F1, POU5F1, POU2F2 ROCK1 2793/4885ROCK2 2165/4885SGK1 1762/4885
US-20160177269-A1 METHODS FOR GENERATING STEM CELL-DERIVED BETA CELLS AND METHODS OF USE THEREOF IAPP, RNASE1, PNLIP ROCK1 2444/4885ROCK2 2425/4885SGK1 2687/4885
US-20190338250-A1 METHODS FOR GENERATING STEM CELL-DERIVED BETA CELLS AND METHODS OF USE THEREOF IAPP, RNASE1, PNLIP ROCK1 2444/4885ROCK2 2425/4885SGK1 2687/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.