Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.37 |
| ▸ | MTOR | P42345 | 7/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7679170 | 0.85 | CYP2C19 (0.53) | KDM4EGAACYP2C19CYP3A4CYP2D6 | |
| SCHEMBL7679097 | 0.83 | CYP2C19 (0.48) | GAAPIK3CAMTORCYP2C19CYP3A4 | |
| SCHEMBL7675925 | 0.81 | CYP2D6 (0.45) | KDM4ECYP2C19CYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL7679073 | 0.71 | CYP3A4 (0.45) | MKNK1KDM4EGAAPIK3CACYP2C19 | |
| SCHEMBL27457509 | 0.69 | KDM4E (0.33) | KDM4ECYP3A4ALDH1A1HPGDHSD17B10 | |
| SCHEMBL7672759 | 0.67 | KDM4E (0.43) | KDM4EPIK3CACYP2C19ALDH1A1HSD17B10 | |
| SCHEMBL7675337 | 0.66 | PIK3R1 (0.40) | KDM4EGAAPIK3CAMTORHSD17B10 | |
| SCHEMBL7673338 | 0.66 | HRH3 (0.40) | PIK3CALRRK2PIK3CGCYP2C9CYP1A2 | |
| SCHEMBL1602160 | 0.64 | KDM4E (0.45) | KDM4EGAAPIK3CAALDH1A1HPGD | |
| SCHEMBL1599910 | 0.64 | KDM4E (0.45) | KDM4EGAAPIK3CAALDH1A1LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6455520-B1 | TUMOR NECROSIS FACTOR AND INTERLEUKIN INHIBITORS; ANTIINFLAMMATORY AGENTS, ANTIALLERGENS; BONE DISORDERS | ASTRA ZENECA AB (SE) | 2002-09-24 | — | — | US | disclosed |