Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 12/20 | 0.38 |
| ▸ | THRB | P10828 | 12/20 | 0.38 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5630623 | 0.92 | NR3C1 (0.85) | NR3C1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7054470 | 0.92 | NR3C1 (0.84) | NR3C1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7053515 | 0.92 | NR3C1 (0.72) | NR3C1CYP1A2CYP2C19THRATHRB | |
| SCHEMBL7054017 | 0.91 | NR3C1 (0.69) | NR3C1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7688423 | 0.91 | NR3C1 (0.69) | NR3C1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7052864 | 0.91 | NR3C1 (0.69) | NR3C1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7677871 | 0.89 | NR3C1 (0.66) | NR3C1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7054015 | 0.89 | NR3C1 (0.66) | NR3C1THRATHRBLMNA | |
| SCHEMBL7049805 | 0.88 | NR3C1 (0.65) | NR3C1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7050858 | 0.87 | NR3C1 (0.64) | NR3C1CYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492424-B1 | Glucocorticoid and thyroid hormone receptor ligands for the treatment of metabolic disorders | KARO BIO AB (SE) | 2002-12-10 | — | — | US | disclosed |