Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.64 |
| ▸ | THRA | P10827 | 13/20 | 0.36 |
| ▸ | THRB | P10828 | 13/20 | 0.36 |
| ▸ | ACACB | O00763 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | GCK | P35557 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7050851 | 0.93 | NR3C1 (0.75) | NR3C1THRATHRBFFAR1 | |
| SCHEMBL7049890 | 0.90 | NR3C1 (0.64) | NR3C1THRATHRBACACBCYP1A2 | |
| SCHEMBL7681978 | 0.87 | NR3C1 (0.71) | NR3C1THRATHRBCYP1A2CYP3A4 | |
| SCHEMBL7688523 | 0.86 | NR3C1 (0.79) | NR3C1THRATHRBCYP1A2CYP2C19 | |
| SCHEMBL5630623 | 0.86 | NR3C1 (0.85) | NR3C1THRATHRBCYP1A2CYP3A4 | |
| SCHEMBL7053515 | 0.86 | NR3C1 (0.72) | NR3C1THRATHRBCYP1A2CYP2C19 | |
| SCHEMBL7054017 | 0.85 | NR3C1 (0.69) | NR3C1THRATHRBCYP1A2CYP3A4 | |
| SCHEMBL7052864 | 0.85 | NR3C1 (0.69) | NR3C1THRATHRBCYP1A2CYP3A4 | |
| SCHEMBL7688423 | 0.85 | NR3C1 (0.69) | NR3C1THRATHRBCYP1A2CYP3A4 | |
| SCHEMBL7054567 | 0.85 | NR3C1 (0.83) | NR3C1THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102739-B1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KAROBIO AB (SE) | 2003-04-23 | — | — | EP | disclosed |
| US-6492424-B1 | Glucocorticoid and thyroid hormone receptor ligands for the treatment of metabolic disorders | KARO BIO AB (SE) | 2002-12-10 | — | — | US | disclosed |
| EP-1102739-A1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KARO BIO AB (SE) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000007972-A1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KARO BIO AB (SE) | 2000-02-17 | — | — | WO | disclosed |