Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | LSS | P48449 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7687965 | 0.86 | LSS (0.49) | KMT2AHPGDNPC1LSSLMNA | |
| SCHEMBL7686578 | 0.85 | KMT2A (0.53) | KMT2AHPGDNPC1LSSLMNA | |
| SCHEMBL7017613 | 0.76 | STS (0.56) | KMT2AHPGDNPC1MAPTNPSR1 | |
| SCHEMBL8040292 | 0.75 | KMT2A (0.57) | KMT2AHPGDNPC1LSSLMNA | |
| SCHEMBL7995493 | 0.73 | LMNA (0.55) | KMT2ALSSLMNAMAPTMEN1 | |
| SCHEMBL18917640 | 0.73 | NPC1 (0.61) | KMT2AHPGDNPC1LMNAMAPT | |
| SCHEMBL2983323 | 0.72 | NPC1 (0.56) | KMT2AHPGDNPC1LSSLMNA | |
| SCHEMBL5754708 | 0.71 | MAPT (0.65) | KMT2AHPGDNPC1LMNAMAPT | |
| SCHEMBL26988530 | 0.71 | KMT2A (0.68) | KMT2AHPGDNPC1LMNAMAPT | |
| SCHEMBL25333107 | 0.71 | KMT2A (0.58) | KMT2AHPGDNPC1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441177-B1 | Tertiary amines | HOFFMANN-LA ROCHE INC. | 2002-08-27 | — | — | US | disclosed |
| US-6034275-A | FUGICIDES; ATICHOLESTEROL AGENTS | HOFFMANN-LA ROCHE INC. (US) | 2000-03-07 | — | — | US | disclosed |