Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.49 |
| ▸ | NOS1 | P29475 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | CHKA | P35790 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CLK3 | P49761 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19116555 | 0.79 | NOS3 (0.55) | NOS3NOS1LRRK2PRMT5WDR77 | |
| SCHEMBL14032704 | 0.79 | KDM4E (0.45) | NOS3NOS1DRD4CHKAPIK3CA | |
| SCHEMBL5131625 | 0.78 | LMNA (0.49) | DRD4CHKAPIK3CAPRMT6TMEM97 | |
| SCHEMBL30240793 | 0.76 | NOS3 (0.52) | NOS3NOS1LRRK2PRMT5WDR77 | |
| SCHEMBL3740610 | 0.76 | NOS3 (0.52) | NOS3NOS1LRRK2PIK3CAPRMT5 | |
| SCHEMBL29203405 | 0.76 | NOS3 (0.52) | NOS3NOS1LRRK2PRMT5WDR77 | |
| SCHEMBL12205229 | 0.75 | LRRK2 (0.51) | NOS3NOS1LRRK2 | |
| SCHEMBL13778529 | 0.74 | MC4R (0.49) | DRD2DRD4DRD3CHKAPRMT6 | |
| SCHEMBL19087150 | 0.74 | NOS3 (0.54) | NOS3NOS1DRD2DRD4DRD3 | |
| SCHEMBL14782170 | 0.73 | LMNA (0.57) | NOS3NOS1DRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6455520-B1 | TUMOR NECROSIS FACTOR AND INTERLEUKIN INHIBITORS; ANTIINFLAMMATORY AGENTS, ANTIALLERGENS; BONE DISORDERS | ASTRA ZENECA AB (SE) | 2002-09-24 | — | — | US | disclosed |