Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 8/20 | 0.46 |
| ▸ | CTSS | P25774 | 6/20 | 0.46 |
| ▸ | CTSL | P07711 | 5/20 | 0.46 |
| ▸ | CTSK | P43235 | 3/20 | 0.46 |
| ▸ | CTSF | Q9UBX1 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947429 | 0.96 | CTSB (0.43) | CTSBCTSSCTSLCTSKCTSF | |
| SCHEMBL6741608 | 0.94 | CTSL (0.46) | CTSBCTSSCTSLCTSKCTSF | |
| SCHEMBL1558021 | 0.94 | CTSL (0.46) | CTSBCTSSCTSLCTSKCTSF | |
| SCHEMBL7658551 | 0.94 | CTSL (0.52) | CTSBCTSSCTSLCTSKCTSF | |
| SCHEMBL6061943 | 0.93 | CTSB (0.48) | CTSBCTSSCTSLCTSKCTSF | |
| SCHEMBL6062326 | 0.92 | CTSB (0.45) | CTSBCTSSCTSLCTSKCTSF | |
| SCHEMBL6062502 | 0.92 | CTSB (0.45) | CTSBCTSSCTSLCTSKCTSF | |
| SCHEMBL6063237 | 0.91 | CTSB (0.44) | CTSBCTSSCTSLCTSKCTSF | |
| SCHEMBL6063030 | 0.90 | CTSB (0.45) | CTSBCTSSCTSLCTSKCTSF | |
| SCHEMBL6061706 | 0.89 | CTSB (0.43) | CTSBCTSSCTSLCTSKCTSF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492362-B1 | Compounds and compositions as cathepsin S inhibitors | AXYS PHARMACEUTICALS, INC. | 2002-12-10 | — | — | US | disclosed |