Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7687189 | 0.84 | SMN1; SMN2 (0.47) | TP53MAPTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL7681208 | 0.82 | LMNA (0.49) | MAPTLMNAALDH1A1HPGDMAOB | |
| SCHEMBL6773220 | 0.80 | MAOB (0.42) | TP53MAPTLMNAALDH1A1MAOB | |
| SCHEMBL7683058 | 0.80 | LMNA (0.47) | MAPTLMNAALDH1A1HPGDHTT | |
| Hydrochloric Acid SCHEMBL7683930 | 0.78 | TP53 (0.35) | TP53MAPTSMN1; SMN2ALDH1A1MAOB | |
| SCHEMBL7685368 | 0.77 | LMNA (0.58) | TP53MAPTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL7371057 | 0.72 | BRD4 (0.44) | TP53MAPTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL4899883 | 0.72 | BRD4 (0.47) | TP53MAPTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL2016019 | 0.72 | LMNA (0.80) | TP53MAPTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL20028528 | 0.69 | TSHR (0.54) | TP53MAPTSMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350749-B1 | SODIUM CHANNEL MODULATORS, ANTIARRHYTHMIA AND HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS, ANGINA PECTORIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-02-26 | — | — | US | disclosed |
| EP-1057812-A1 | AMINOGUANIDINE HYDRAZONE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND DRUGS THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |