Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAP1LC3B | Q9GZQ8 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.39 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7683058 | 0.89 | LMNA (0.47) | LMNAALOX15TSHRHSD17B10HSP90AA1 | |
| SCHEMBL7682872 | 0.82 | TP53 (0.52) | LMNAALOX15TSHRHSD17B10HSP90AA1 | |
| SCHEMBL7685368 | 0.79 | LMNA (0.58) | LMNAALOX15TSHRHSD17B10HSP90AA1 | |
| SCHEMBL7686913 | 0.76 | LMNA (0.48) | LMNAALOX15TSHRHSD17B10HSP90AA1 | |
| SCHEMBL6947652 | 0.76 | HTR2A (0.34) | ALOX15TSHRHSD17B10ALDH1A1HPGD | |
| SCHEMBL6948898 | 0.70 | MAOB (0.36) | MAOB | |
| SCHEMBL7683472 | 0.68 | MAP1LC3B (0.47) | LMNAALOX15TSHRHSD17B10HSP90AA1 | |
| SCHEMBL6762871 | 0.67 | NAMPT (0.40) | HSD17B10ALDH1A1HPGDKMT2ARAB9A | |
| SCHEMBL760652 | 0.67 | NAMPT (0.42) | HSD17B10ALDH1A1HPGDGAAMAPT | |
| SCHEMBL16943023 | 0.66 | LDHA (0.35) | MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350749-B1 | SODIUM CHANNEL MODULATORS, ANTIARRHYTHMIA AND HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS, ANGINA PECTORIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-02-26 | — | — | US | disclosed |
| EP-1057812-A1 | AMINOGUANIDINE HYDRAZONE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND DRUGS THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |