Sugi Predict

Sugi Predict / Compounds / SCHEMBL7683231

SCHEMBL7683231

SCHEMBL7683231

O=C(O)c1ccc(OC(F)(F)F)cc1[N+](=O)[O-]

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ EIF4E P06730 1/20 0.47
▸ MEN1 O00255 3/20 0.45
▸ KMT2A Q03164 3/20 0.45
▸ TDP1 Q9NUW8 2/20 0.45
▸ TTR P02766 1/20 0.45
▸ PPOX P50336 1/20 0.45
▸ MITF O75030 1/20 0.44
▸ SMN1; SMN2 Q16637 1/20 0.44
▸ AKR1C2 P52895 5/20 0.44
▸ AKR1C1 Q04828 3/20 0.44
▸ PIM1 P11309 1/20 0.43
▸ DHODH Q02127 1/20 0.43
▸ AKR1C3 P42330 4/20 0.43
▸ MAPT P10636 2/20 0.43
▸ HTT P42858 2/20 0.43
▸ TP53 P04637 1/20 0.43
▸ CASP3 P42574 1/20 0.43
▸ NPSR1 Q6W5P4 1/20 0.43
▸ SENP7 Q9BQF6 1/20 0.43
▸ IGF2BP2 Q9Y6M1 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3158027 0.88 MEN1 (0.57) EIF4EMEN1KMT2ATDP1TTR
SCHEMBL9704851 0.87 MEN1 (0.43) EIF4EMEN1KMT2ATDP1TTR
SCHEMBL22749364 0.87 KMT2A (0.43) EIF4EMEN1KMT2AMITFSMN1; SMN2
SCHEMBL7688039 0.85 MEN1 (0.45) MEN1KMT2ATDP1MITFSMN1; SMN2
SCHEMBL9300807 0.83 EIF4E (0.47) EIF4EMEN1KMT2ATDP1TTR
SCHEMBL5454437 0.80 MEN1 (0.41) EIF4EMEN1KMT2ATDP1TTR
SCHEMBL5454433 0.80 MEN1 (0.41) EIF4EMEN1KMT2ATDP1TTR
SCHEMBL147187 0.80 AKR1C3 (0.63) MEN1KMT2ASMN1; SMN2AKR1C2AKR1C1
SCHEMBL707416 0.80 SMN1; SMN2 (0.51) MEN1KMT2AMITFSMN1; SMN2MAPT
SCHEMBL26099615 0.79 TSHR (0.48) EIF4EMEN1KMT2ATDP1TTR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0506907-A1 HETEROCYCLIC DIONE DERIVATIVES AS PESTICIDES AND PLANT GROWTH REGULATORS SANDOZ-ERFINDUNGEN Verwaltungsgesellschaft m.b.H. (AT) 1992-10-07 — — EP claimed
WO-1992007837-A1 HETEROCYCLIC DIONE DERIVATIVES AS PESTICIDES AND PLANT GROWTH REGULATORS SANDOZ LTD. (CH) 1992-05-14 — — WO claimed
WO-2026087613-A1 3-AZA-BICYCLO[3.3.0]OCTANE COMPOUNDS, PREPARATION AND THERAPEUTIC USES THEREOF SANOFI (FR) 2026-04-30 — — WO disclosed
EP-4698531-A1 PYRROLOPYRAZINE COMPOUNDS, PREPARATION THEREOF AND THERAPEUTIC USES THEREOF Sanofi (FR) 2026-02-25 — — EP disclosed
US-20260022116-A1 IMIDAZOPYRIDINE COMPOUNDS, PREPARATION THEREOF AND THERAPEUTIC USES THEREOF SANOFI-AVENTIS RECHERCHE & DÉVELOPPEMENT (FR) 2026-01-22 — — US disclosed
EP-4558500-A1 IMIDAZOPYRIDINE COMPOUNDS, PREPARATION THEREOF AND THERAPEUTIC USES THEREOF Sanofi (FR) 2025-05-28 — — EP disclosed
WO-2024218235-A1 PYRROLOPYRAZINE COMPOUNDS, PREPARATION THEREOF AND THERAPEUTIC USES THEREOF SANOFI (FR) 2024-10-24 — — WO disclosed
CN-114728910-B Pyrazole derivative for FGFR inhibitor and preparation method thereof 上海奕拓医药科技有限责任公司 2024-05-14 — — CN disclosed
WO-2024017977-A1 IMIDAZOPYRIDINE COMPOUNDS, PREPARATION THEREOF AND THERAPEUTIC USES THEREOF SANOFI (FR) 2024-01-25 — — WO disclosed
US-20220298143-A1 Pyrazole Derivatives for FGFR Inhibitor and Preparation Method Thereof ETERN BIOPHARMA (SHANGHAI) CO., LTD. (CN) 2022-09-22 — — US disclosed
CN-114728910-A Pyrazole derivatives for FGFR inhibitor and preparation method thereof 上海奕拓医药科技有限责任公司 2022-07-08 — — CN disclosed
WO-2019057969-A1 DUAL AGONISTS OF FXR AND PPARδ AND THEIR USES Johann Wolfgang Goethe-Universität (DE) 2019-03-28 — — WO disclosed
US-20020045551-A1 4-benzoyl isoxazoles derivatives and their use as herbicides MUSIL TIBOR (GB) 2002-04-18 — — US disclosed
US-6323155-B1 EXCELLENT LEVEL OF HERBICIDAL ACTIVITY TOGETHER WITH CROP TOLERANCE RHONE-POULENC AGRICULTURE LIMITED (GB) 2001-11-27 — — US disclosed
EP-0674629-B1 4-BENZOYL ISOXAZOLES DERIVATIVES AND THEIR USE AS HERBICIDES RHONE POULENC AGRICULTURE (GB) 1998-07-08 — — EP disclosed
EP-0674629-A1 4-BENZOYL ISOXAZOLES DERIVATIVES AND THEIR USE AS HERBICIDES RHONE-POULENC AGRICULTURE LTD. (GB) 1995-10-04 — — EP disclosed
EP-0625505-A2 2-Cyano-1,3-dione derivatives and their use as herbicides RHONE POULENC AGRICULTURE LTD. (GB) 1994-11-23 — — EP disclosed
WO-1994014782-A1 4-BENZOYL ISOXAZOLES DERIVATIVES AND THEIR USE AS HERBICIDES RHONE-POULENC AGRICULTURE LTD. (GB) 1994-07-07 — — WO disclosed
EP-0506907-A1 HETEROCYCLIC DIONE DERIVATIVES AS PESTICIDES AND PLANT GROWTH REGULATORS SANDOZ-ERFINDUNGEN Verwaltungsgesellschaft m.b.H. (AT) 1992-10-07 — — EP disclosed
WO-1992007837-A1 HETEROCYCLIC DIONE DERIVATIVES AS PESTICIDES AND PLANT GROWTH REGULATORS SANDOZ LTD. (CH) 1992-05-14 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020045551-A1 4-benzoyl isoxazoles derivatives and their use as herbicides CBR3, CBR1, GLRA3 EIF4E 4160/4885MEN1 4809/4885KMT2A 3499/4885
US-20220298143-A1 Pyrazole Derivatives for FGFR Inhibitor and Preparation Method Thereof FGFR1, FGFR2, FGFR3 EIF4E 1809/4885MEN1 2796/4885KMT2A 2107/4885
US-20260022116-A1 IMIDAZOPYRIDINE COMPOUNDS, PREPARATION THEREOF AND THERAPEUTIC USES THEREOF MAPK1, MAPK3, MAPK6 EIF4E 97/4885MEN1 2622/4885KMT2A 2403/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.